Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain

被引:14
作者
Ichinose, Takashi [1 ]
Moriyasu, Kazuki [1 ]
Nakahata, Akane [1 ]
Tanaka, Mitsuru [2 ]
Matsui, Toshiro [2 ]
Furuya, Shigeki [1 ,3 ]
机构
[1] Kyushu Univ, Dept Biosci & Biotechnol, Lab Funct Genom & Metab, Grad Sch Bioresource & Bioenvironm Sci, Fukuoka 812, Japan
[2] Kyushu Univ, Dept Biosci & Biotechnol, Lab Food Anal, Grad Sch Bioresource & Bioenvironm Sci, Fukuoka 812, Japan
[3] Kyushu Univ, Bioarchitecture Ctr, Fukuoka 812, Japan
关键词
tyrosine; dipeptide; noradrenaline; soy; brain; BIOACTIVE PEPTIDES; NOREPINEPHRINE; TYROSINE; RELEASE; MOOD;
D O I
10.1080/09168451.2015.1044932
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose sequences are present frequently in soy proteins, Ser-Tyr (SY), Ile-Tyr, and Tyr-Pro had the highest apparent permeability coefficients in monolayers of human intestinal epithelial Caco-2 cells. When administrated orally, SY markedly increased tyrosine content in the cerebral cortex compared to the vehicle control, Ile-Tyr, Tyr-Pro, and Y alone. The oral administration of SY more effectively increased 3-methoxy-4-hydroxyphenylethyleneglycol, the principal metabolite of noradrenaline, in the cerebral cortex and hippocampus than did Ile-Tyr, Tyr-Pro, or Y alone. Central noradrenergic turnover was also markedly stimulated by SY administration. These in vivo observations strongly suggest that SY is more potent in boosting central catecholamine transmission, particularly the noradrenergic system, than Y alone or other dipeptides that include Y.
引用
收藏
页码:1542 / 1547
页数:6
相关论文
共 17 条
[1]  
Esaki K, 2011, J NUTR FOOD SCI, V1, P109, DOI [10.4172/2155-9600.1000109., DOI 10.4172/2155-9600.1000109]
[2]   Increased Tyrosine in the Brain and Serum of Mice by Orally Administering Dipeptide SY [J].
Esaki, Kayoko ;
Ohmori, Taketo ;
Maebuchi, Motohiro ;
Nakamori, Toshihiro ;
Ohshima, Toshihisa ;
Furuya, Shigeki .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2013, 77 (04) :847-849
[3]   Food-derived peptides with biological activity: from research to food applications [J].
Hartmann, Rainer ;
Meisel, Hans .
CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (02) :163-169
[4]   Discovering endophenotypes for major depression [J].
Hasler, G ;
Drevets, WC ;
Manji, HK ;
Charney, DS .
NEUROPSYCHOPHARMACOLOGY, 2004, 29 (10) :1765-1781
[5]   Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo [J].
Inoue, Nao ;
Nagao, Koji ;
Sakata, Kotaro ;
Yamano, Naomi ;
Gunawardena, Pathma Elgoda Ranawakage ;
Han, Seo-Young ;
Matsui, Toshiro ;
Nakamori, Toshihiro ;
Furuta, Hitoshi ;
Takamatsu, Kiyoharu ;
Yanagita, Teruyoshi .
LIPIDS IN HEALTH AND DISEASE, 2011, 10
[6]   Bioactive peptides: Production and functionality [J].
Korhonen, Hannu ;
Pihlanto, Anne .
INTERNATIONAL DAIRY JOURNAL, 2006, 16 (09) :945-960
[7]   Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness -: Evidence in support of the catecholamine hypothesis of mood disorders [J].
Lambert, G ;
Johansson, M ;
Ågren, H ;
Friberg, P .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (08) :787-793
[8]   Tyrosine prevents effects of hyperthermia on behavior and increases norepinephrine [J].
Lieberman, HR ;
Georgelis, JH ;
Maher, TJ ;
Yeghiayan, SK .
PHYSIOLOGY & BEHAVIOR, 2005, 84 (01) :33-38
[9]  
MENDELS J, 1974, ARCH GEN PSYCHIAT, V30, P447
[10]   Bioactive peptides and proteins from foods:: indication for health effects [J].
Moller, Niels Peter ;
Scholz-Ahrens, Katharina Elisabeth ;
Roos, Nils ;
Schrezenmeir, Juergen .
EUROPEAN JOURNAL OF NUTRITION, 2008, 47 (04) :171-182