Synthesis and anticancer activity evaluation of some acridine derivatives

被引：23

作者：

Arya, Surbhi ^{[1
]}

Kumar, Anuj ^{[1
]}

Kumar, Nikhil ^{[2
]}

Roy, Partha ^{[2
]}

Sondhi, S. M. ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Indian Inst Technol Roorkee, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 05期

关键词：

Synthesis; Acridine derivatives; Human cancer cell lines; Anticancer; BIOLOGICAL EVALUATION;

D O I：

10.1007/s00044-014-1268-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

9-Amino acridine derivatives (1a-1h) on condensation with 9, 10-dihydroanthracene-9, 10-alpha, beta-succinic anhydride (2) at room temperature gave condensation products (3a-3h). Microwave-assisted condensation of 9-amino acridine derivatives (1a-1d) with phthalic anhydride, cis 1,2,3,6-tetrahydrophthalimide, and 2,5-pyrroledione gave corresponding condensation products 4a-4d, 5a-5d & 6a-6d, respectively, in good yields. All these compounds were screened for in vitro anticancer activity against five human cancer cell lines i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1), and liver (Hep G2). Compounds 3a (breast T47D), 3 g (lung NCl H-522), 4a (liver Hep G2), and 6b (colon HCT-15) exhibited IC50 values 5.4, 4.2, 4.5, and 2.4 A mu M, respectively, and hence possess good anticancer activity.

引用

页码：1942 / 1951

页数：10

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