Blood transfusion services for patients with sickle cell disease in Nigeria

被引：21

作者：

Diaku-Akinwumi, Ijeoma N. ^{[1
]}

Abubakar, Sani B. ^{[2
]}

Adegoke, Samuel A. ^{[3
]}

Adeleke, Solomon ^{[4
,5
]}

Adewoye, Oyebade ^{[6
]}

Adeyemo, Titilayo ^{[7
]}

Akinbami, Akinsegun ^{[8
]}

Akinola, Norah O. ^{[9
]}

Akinsulie, Adebola ^{[10
]}

Akinyoola, Adeline ^{[11
]}

Aneke, John ^{[12
]}

Awwalu, Sani ^{[13
]}

Babadoko, Ahmadu ^{[13
]}

Brown, Biobele ^{[14
]}

Ejike, Obuoha ^{[15
]}

Emodi, Ifeoma ^{[16
]}

George, Innocent ^{[17
]}

Girei, Ahmed ^{[18
]}

Hassan, Abdulaziz ^{[13
]}

Kangiwa, Garba U. ^{[19
]}

Lawal, Olubunmi A. ^{[20
]}

Mabogunje, Cecilia ^{[21
]}

Madu, Anazoeze J. ^{[22
]}

Mustapha, Akeem ^{[23
]}

Ndakotsu, Muhammad ^{[2
]}

Nnodu, Obiageli E. ^{[4
,5
]}

Nwaneri, Damian ^{[24
]}

Odey F, Friday ^{[25
]}

Ohiaeri, Chinatu ^{[26
]}

Olaosebikan, Rasaq ^{[27
]}

Olatunya O, Oladele S. ^{[28
]}

Oniyangi, Oluseyi ^{[29
]}

Opara, Hyginus ^{[30
]}

Ugwu, Ngozi I. ^{[31
]}

Musa, Abubakar U. ^{[2
]}

Abdullahi, Shehu ^{[32
]}

Usman, Abubakar ^{[33
]}

Utuk, Enobong ^{[34
]}

Jibir, Binta W. ^{[35
]}

Adekile, Adekunle D. ^{[36
]}

机构：

[1] Lagos State Univ, Teaching Hosp, Dept Pediat, Lagos, Nigeria

[2] Uthman Danfodio Univ, Teaching Hosp, Dept Pediat, Sokoto, Nigeria

[3] Obafemi Awolowo Univ, Teaching Hosp, Dept Pediat, Wesley Guild Hosp,Ilesa Unit, Ife, Nigeria

[4] Univ Abuja, Dept Pediat, Abuja, Nigeria

[5] Univ Abuja, Teaching Hosp, Abuja, Nigeria

[6] Gen Hosp, Dept Hematol, Katsina, Nigeria

[7] Univ Lagos, Teaching Hosp, Dept Hematol, Lagos, Nigeria

[8] Lagos State Univ, Teaching Hosp, Dept Hematol, Lagos, Nigeria

[9] Obafemi Awolowo Univ, Dept Hematol, Ife, Nigeria

[10] Univ Lagos, Teaching Hosp, Dept Pediat, Lagos, Nigeria

[11] Gbagada Gen Hosp, Lagos, Nigeria

[12] Nnamdi Azikiwe Univ, Teaching Hosp, Zaria, Nigeria

[13] Ahmadu Bello Univ, Teaching Hosp, Zaria, Nigeria

[14] Univ Coll Hosp, Dept Pediat, Ibadan, Nigeria

[15] Enugu State Univ, Teaching Hosp, Parklane, Nigeria

[16] Univ Nigeria, Teaching Hosp, Dept Pediat, Enugu, Nigeria

[17] Univ Port Harcourt, Teaching Hosp, Dept Pediat, Port Harcourt, Nigeria

[18] Fed Med Ctr, Gombe, Nigeria

[19] Fed Med Ctr, Birnin Kebbi, Nigeria

[20] Fed Med Ctr, Dept Pediat, Iddo Ekiti, Nigeria

[21] Massey St Childrens Hosp, Enugu, Nigeria

[22] Univ Nigeria, Teaching Hosp, Dept Hematol, Enugu, Nigeria

[23] Ifako Ijaiye Gen Hosp, Lagos, Nigeria

[24] Univ Benin, Teaching Hosp, Dept Child Hlth, Dept Hematol, Benin, Nigeria

[25] Univ Calabar, Teaching Hosp, Dept Pediat, Calabar, Nigeria

[26] Fed Med Ctr, Dept Pediat, Keffi, Nigeria

[27] Univ Ilorin, Teaching Hosp, Dept Pediat, Ilorin, Nigeria

[28] Ekiti State Univ, Dept Pediat, Ado Ekiti, Nigeria

[29] Natl Hosp, Dept Pediat, Abuja, Nigeria

[30] Fed Med Ctr, Dept Pediat, Asaba, Nigeria

[31] Fed Teaching Hosp, Dept Haematol, Abakaliki, Nigeria

[32] Aminu Kano Teaching Hosp, Dept Pediat, Kano, Nigeria

[33] Fed Med Ctr, Dept Pediat, Bida, Nigeria

[34] Univ Uyo, Teaching Hosp, Dept Pediat, Uyo, Nigeria

[35] Murtala Muhammed Specialist Hosp Kano, Dept Pediat, Kano, Nigeria

[36] Kuwait Univ, Dept Pediat, Kuwait, Kuwait

来源：

INTERNATIONAL HEALTH | 2016年 / 8卷 / 05期

关键词：

Blood transfusion; Nigeria; Sickle cell disease; DOPPLER FLOW VELOCITIES; CHILDREN; ANEMIA; ALLOIMMUNIZATION; PREVALENCE; MANAGEMENT; IRON;

D O I：

10.1093/inthealth/ihw014

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Safe, timely red blood cell transfusion saves lives and chronic transfusion therapy (CTT) prevents or limits morbidities such as stroke, therefore improving quality of life of patients with sickle cell disease (SCD). This questionnaire-based study assessed the ability of sickle cell centers in Nigeria to provide safe blood to patients with SCD between March and August 2014. Out of the 73 hospitals contacted, responses were obtained from 31. Twenty four (78%) hospitals were unable to transfuse patients regularly due to blood scarcity. Packed red blood cells were available in 14 (45%), while only one provided leukocyte-depletion. Most centers assessed donor risk and screened for HIV in 30 (97%), hepatitis B in 31(100%) and hepatitis C in 27 (87%) hospitals. Extended phenotyping and alloantibody screening were not available in any center. A quarter of the hospitals could monitor iron overload, but only using serum ferritin. Access to iron chelators was limited and expensive. Seventeen (55%) tertiary hospitals offered CTT by top-up or manual exchange transfusion; previous stroke was the most common indication. Current efforts of Nigerian public hospitals to provide safe blood and CTT fall short of best practice. Provision of apheresis machines, improvement of voluntary non-remunerated donor drive, screening for red cell antigens and antibodies, and availability of iron chelators would significantly improve SCD care in Nigeria.

引用

页码：330 / 335

页数：6

共 25 条

[1] Sickle cell disease clinical phenotypes in children from South-Western, Nigeria [J].

Adegoke, S. A. ;

Adeodu, O. O. ;

Adekile, A. D. .

NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2015, 18 (01) :95-101

[2]

Adewoyin Ademola Samson, 2014, Adv Hematol, V2014, P923593, DOI 10.1155/2014/923593

[3] Adequacy and pattern of blood donations in north-eastern Nigeria: the implications for blood safety [J].

Ahmed, S. G. ;

Ibrahim, U. A. ;

Hassan, A. W. .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2007, 101 (08) :725-731

[4]

Akodu SO, 2011, NIGERIAN HOSP PRACTI, V8, P69

[5]

Ejiofor OS, 2009, NIGER J CLIN PRACT, V12, P355

[6]

Ekwere TA., 2014, Int J Blood Transfus Immunohematol, V4, P7

[7]

Garg P, 2015, INDIAN J APPL RES, V5, P428

[8]

George I.O., 2011, African Journal of Hematology and Oncology, V2, P187

[9] Nontransferrin-bound iron in transfused patients with sickle cell disease [J].

Inati, A. ;

Musallam, K. M. ;

Cappellini, M. D. ;

Duca, L. ;

Taher, A. T. .

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2011, 33 (02) :133-137

[10] Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort [J].

Lagunju, IkeOluwa ;

Brown, Biobele J. ;

Sodeinde, Olugbemiro .

PEDIATRIC BLOOD & CANCER, 2015, 62 (09) :1587-1591

← 1 2 3 →