Stress granules, P-bodies and cancer

被引：260

作者：

Anderson, Paul ^{[1
]}

Kedersha, Nancy

Ivanov, Pavel ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2015年 / 1849卷 / 07期

关键词：

Cancer; Stress granule; P-body; Post-transcriptional regulation; Apoptosis; Stress response; MESSENGER-RNA DECAY; EUKARYOTIC TRANSLATION INITIATION; NATURAL-PRODUCT PATEAMINE; MICRORNA-DEPENDENT LOCALIZATION; TO-MESENCHYMAL TRANSITION; BINDING PROTEIN HUR; PROCESSING BODIES; GENE-EXPRESSION; BODY FORMATION; RIBONUCLEASE INHIBITOR;

D O I：

10.1016/j.bbagrm.2014.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic machinery, and stress response programs. This review examines evidence implicating RNA granules in the pathogenesis of cancer and discusses their potential as targets for anticancer therapies. This article is part of a Special Issue entitled: Translation and Cancer. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：861 / 870

页数：10

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