Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

被引：4

作者：

Hiranrattana, Anunya ^{[1
]}

Stern, Debra A. ^{[2
]}

Guerra, Stefano ^{[2
]}

Halonen, Marilyn ^{[2
]}

Wright, Anne L. ^{[1
,2
]}

Daines, Michael ^{[1
,2
]}

Martinez, Fernando D. ^{[2
]}

Morgan, Wayne J. ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Pediat, Pediat Pulm Allergy Div, Tucson, AZ 85721 USA

[2] Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ 85724 USA

来源：

THORAX | 2018年 / 73卷 / 12期

基金：

美国国家卫生研究院;

关键词：

allergic lung disease; asthma; asthma epidemiology; OBESITY; METHACHOLINE; RESPONSIVENESS; INFLAMMATION; WEIGHT;

D O I：

10.1136/thoraxjnl-2017-210325

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

引用

页码：1170 / 1173

页数：4

共 11 条

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