Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

被引：8

作者：

Royle, Jamie ^{[1
]}

Donald, Claire L. ^{[1
]}

Merits, Andres ^{[2
]}

Kohl, Alain ^{[1
]}

Varjak, Margus ^{[1
]}

机构：

[1] Univ Glasgow, Ctr Virus Res, MRC, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Tartu, Inst Technol, Nooruse 1, EE-50411 Tartu, Estonia

来源：

VETERINARY JOURNAL | 2017年 / 230卷

基金：

英国医学研究理事会;

关键词：

Zika virus; Semliki Forest virus; Lipid biosynthesis; Antiviral agent; FATTY-ACID SYNTHASE; INFECTION; DENGUE;

D O I：

10.1016/j.tvjl.2017.10.009

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae). (C) 2017 The Authors. Published by Elsevier Ltd.

引用

页码：62 / 64

页数：3

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