Thermo-Responsive Mn-Zn Ferrite/Poly(N,N′-Isopropyl Acrylamide-co-N-Hydroxymethylacrylamide) Core/Shell Nanocomposites for Drug-Delivery Systems

被引：12
作者：
Cao Yang [1 ]
Ren Jie [1 ,2 ]
Li Jianbo [1 ]
Liu Yan [1 ]
机构：
[1] Tongji Univ, Sch Mat Sci & Engn, Inst Nano & Biopolymer Mat, Shanghai 200092, Peoples R China
[2] Tongji Univ, Key Lab Adv Civil Engn, Minist Educ, Shanghai 200092, Peoples R China
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2011年 / 22卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Thermosensitivity; magnetic nanoparticles; nanocomposites; drug carrier; BLOCK-COPOLYMER; MAGNETITE NANOPARTICLES; MOLECULAR RECOGNITION; MEDIATED HYPERTHERMIA; POLYMER; PH; RELEASE; TEMPERATURE; MICELLES; CARRIER;
D O I：
10.1163/092050610X512117
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A kind of thermo-sensitive core/shell nanoparticles (Mn-Zn ferrite/poly(N,N'-isopropylacrylamide-co-N-hydroxymethylacrylamide)) has been designed in this work. By using the surface initiated method, a thermo-responsive co-polymer composed of N,N'-isopropylacrylamide (NIPAAm) and N-hydroxymethylacryl-amide (HMAAm) was grafted from ferrite core. The nanoparticles obtained were characterized by FT-IR, XRD, TGA, HRTEM and DLS. The HRTEM observation showed a clear contrast between an ordered crystalline core and a light amorphous polymeric coating. DLS results confirmed the temperature sensitivity of the nanoparticles. In vitro hyperthermia showed well-controlled self-heating properties, indicating that the nanoparticles could potentially be used as an anticancer drug carrier in the biomedical field. (C) Koninklijke Brill NV, Leiden, 2011
引用
收藏
页码：1473 / 1486
页数：14
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