Actin-binding proteins take the reins in growth cones

被引：124

作者：

Pak, Chi W. ^{[2
]}

Flynn, Kevin C. ^{[3
]}

Bamburg, James R. ^{[1
]}

机构：

[1] Colorado State Univ, Mol Cellular & Integrat Neurosci Program, Ft Collins, CO 80523 USA

[2] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

[3] Colorado State Univ, Grad Program Cell & Mol Biol, Ft Collins, CO 80523 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 02期

关键词：

D O I：

10.1038/nrn2236

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Higher-order actin-based networks (actin superstructures) are important for growth-cone motility and guidance. Principles for generating, organizing and remodelling actin superstructures have emerged from recent findings in cell-free systems, non-neuronal cells and growth cones. This Review examines how actin superstructures are initiated de novo at the leading-edge membrane and how the spontaneous organization of actin superstructures is driven by ensembles of actin-binding proteins. How the regulation of actin-binding proteins can affect growth-cone turning and axonal regeneration is also discussed.

引用

页码：136 / 147

页数：12

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