The properties and applications of single-molecule DNA sequencing

被引：74
作者：
Thompson, John F. [1 ]
Milos, Patrice M. [1 ]
机构：
[1] Helicos BioSci Corp, Cambridge, MA 02139 USA
来源：
GENOME BIOLOGY | 2011年 / 12卷 / 02期
基金：
美国国家卫生研究院;
关键词：
DATABASE RESOURCES; NATIONAL CENTER; RNA; TRANSLOCATION; TRANSCRIPTOME; NUCLEOTIDES; RECOGNITION; CHALLENGES; GRAPHENE; YEAST;
D O I：
10.1186/gb-2011-12-2-217
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Single-molecule sequencing enables DNA or RNA to be sequenced directly from biological samples, making it well-suited for diagnostic and clinical applications. Here we review the properties and applications of this rapidly evolving and promising technology.
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页数：10
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