Functionalized graphene oxide coating on Ti6Al4V alloy for improved biocompatibility and corrosion resistance

被引：53
作者：
Asgar, Hassnain [1 ]
Deen, K. M. [2 ,3 ]
Rahman, Zia Ur [4 ]
Shah, Umair Hussain [1 ]
Raza, Mohsin Ali [3 ]
Haider, Waseem [1 ,4 ]
机构：
[1] Cent Michigan Univ, Sch Engn & Technol, Mt Pleasant, MI 48859 USA
[2] Univ British Columbia, Dept Mat Engn, Vancouver, BC V6T 1Z4, Canada
[3] Univ Punjab, CEET, Dept Met & Mat Engn, Lahore 54590, Pakistan
[4] Cent Michigan Univ, Sci Adv Mat, Mt Pleasant, MI 48859 USA
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 94卷
关键词：
Graphene oxide; Titanium; Electrophoretic deposition; Contact angle; Cell viability; Linear polarization resistance; TITANIUM; WETTABILITY; DEPOSITION; EMISSION; IMPLANTS; ADHESION;
D O I：
10.1016/j.msec.2018.10.046
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The present study focused on the development of magnesium-functionalized graphene oxide (FGO) coating on titanium alloy (Ti6Al4V) by electrophoretic deposition. Graphene oxide (GO) was synthesized by modified Hummers' method and functionalized with magnesium ions. X-ray diffraction, infrared spectroscopy (IR) and Raman spectroscopy were employed to confirm the synthesis of GO and GO-coatings on T16Al4V. Functionalization of GO with Mg ions was confirmed by energy dispersive X-ray spectroscopy. The surface morphology of coated samples was examined through scanning electron microscopy. Reduction of FGO coating (labelled as rFGO) by heating at 200 degrees C was confirmed by IR. The rFGO coated Ti6Al4V was found to be hydrophilic in nature as determined by contact angle measurement which showed reduction in the contact angle of Ti6A14V from 95.4 degrees to 42.1 degrees. The percent cell viability over the coated sample was appreciably improved compared to as-received Ti6Al4V sample owing to hydrophilicity of the former. The positive shift in open circuit potential and increase in polarization resistance was observed after coating Ti6Al4V samples with FGO. The significant decrease in the corrosion current density and negative polarization loop in the reverse scan of samples also confirmed the improved corrosion resistance of rFGO-coated Ti6Al4V over uncoated Ti6Al4V in the PBS solution. Furthermore, the impedance spectroscopy revealed that the preferential adsorption of ionic species (indicated by large R-ads) at the surface improved the barrier characteristics of rFGO coated samples and exhibited an order of magnitude higher R-c(t) compared to as-received samples.
引用
收藏
页码：920 / 928
页数：9
相关论文
共 51 条
[11]   Electrophoretic deposition of graphene oxide as a corrosion inhibitor for sintered NdFeB [J].
He, Wenting ;
Zhu, Liqun ;
Chen, Haining ;
Nan, Haiyang ;
Li, Weiping ;
Liu, Huicong ;
Wang, Yan .
APPLIED SURFACE SCIENCE, 2013, 279 :416-423
[12]   Promotion of osteoblast proliferation on complex coacervation-based hyaluronic acid - recombinant mussel adhesive protein coatings on titanium [J].
Hwang, Dong Soo ;
Waite, J. Herbert ;
Tirrell, Matthew .
BIOMATERIALS, 2010, 31 (06) :1080-1084
[13]   Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration [J].
Jung, Ho Sang ;
Choi, Yeong-jin ;
Jeong, Jiwon ;
Lee, Yongmoon ;
Hwang, Byungwoo ;
Jang, Jinah ;
Shim, Jin-Hyung ;
Kim, Yun Seop ;
Choi, Hyun Sik ;
Oh, Sang Ho ;
Lee, Chong Soo ;
Cho, Dong-Woo ;
Hahn, Sei Kwang .
RSC ADVANCES, 2016, 6 (32) :26719-26724
[14]   Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications [J].
Jung, Ho Sang ;
Lee, Taekyung ;
Kwon, Il Keun ;
Kim, Hyoung Seop ;
Hahn, Sei Kwang ;
Lee, Chong Soo .
ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (18) :9598-9607
[15]   Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells [J].
Kalbacova, Marie ;
Broz, Antonin ;
Kong, Jing ;
Kalbac, Martin .
CARBON, 2010, 48 (15) :4323-4329
[16]   Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds [J].
Kim, Kyobum ;
Dean, David ;
Lu, Anqi ;
Mikos, Antonios G. ;
Fisher, John P. .
ACTA BIOMATERIALIA, 2011, 7 (03) :1249-1264
[17]   The Chemical and structural analysis of graphene oxide with different degrees of oxidation [J].
Krishnamoorthy, Karthikeyan ;
Veerapandian, Murugan ;
Yun, Kyusik ;
Kim, S. -J. .
CARBON, 2013, 53 :38-49
[18]   Graphene oxide/hydroxyapatite composite coatings fabricated by electrophoretic nanotechnology for biological applications [J].
Li, Ming ;
Liu, Qian ;
Jia, Zhaojun ;
Xu, Xuchen ;
Cheng, Yan ;
Zheng, Yufeng ;
Xi, Tingfei ;
Wei, Shicheng .
CARBON, 2014, 67 :185-197
[19]   Electrophoretic deposition and electrochemical behavior of novel graphene oxide-hyaluronic acid-hydroxyapatite nanocomposite coatings [J].
Li, Ming ;
Liu, Qian ;
Jia, Zhaojun ;
Xu, Xuchen ;
Shi, Yuying ;
Cheng, Yan ;
Zheng, Yufeng ;
Xi, Tingfei ;
Wei, Shicheng .
APPLIED SURFACE SCIENCE, 2013, 284 :804-810
[20]   Surface energy effects on osteoblast spatial growth and mineralization [J].
Lim, Jung Yul ;
Shaughnessy, Michael C. ;
Zhou, Zhiyi ;
Noh, Hyeran ;
Vogler, Erwin A. ;
Donahue, Henry J. .
BIOMATERIALS, 2008, 29 (12) :1776-1784
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