Input Overload: Contributions of Retinoic Acid Signaling Feedback Mechanisms to Heart Development and Teratogenesis

被引：35

作者：

D'Aniello, Enrico

Waxman, Joshua S. ^{[1
,2
]}

机构：

[1] Cincinnati Childrens Res Fdn, Mol Cardiovasc Biol Div, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Res Fdn, Inst Heart, Cincinnati, OH 45229 USA

来源：

DEVELOPMENTAL DYNAMICS | 2015年 / 244卷 / 03期

关键词：

retinoic acid; vitamin A; development; signaling feedback; transcriptional regulation; teratogenesis; vertebrates; heart; cardiac progenitors; patterning; morphogen; CENTRAL-NERVOUS-SYSTEM; VITAMIN-A HOMEOSTASIS; MATTHEW-WOOD-SYNDROME; RAR DOUBLE MUTANTS; BINDING-PROTEIN-I; ACTIVE REPRESSION; MOUSE DEVELOPMENT; CYP26; ENZYMES; TARGET GENES; ALL-TRANS;

D O I：

10.1002/dvdy.24232

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Appropriate levels of retinoic acid (RA) signaling are critical for normal heart development in vertebrates. A fascinating property of RA signaling is the thoroughness by which positive and negative feedback are employed to promote proper embryonic RA levels. In the present short review, we first cover the advancement of hypotheses regarding the impact of RA signaling on cardiac specification. We then discuss our current understanding of RA signaling feedback mechanisms and the implications of recent studies, which have indicated improperly maintained RA signaling feedback can be a contributing factor to developmental malformations. Developmental Dynamics 244:513-523, 2015. (c) 2014 Wiley Periodicals, Inc.

引用

页码：513 / 523

页数：11

共 135 条

[1] The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures [J].