A viral kinase mimics S6 kinase to enhance cell proliferation

被引：29

作者：

Bhatt, Aadra Prashant ^{[1
,2
]}

Wong, Jason P. ^{[1
,2
]}

Weinberg, Marc S. ^{[3
]}

Host, Kurtis M. ^{[1
,2
]}

Giffin, Louise C. ^{[1
,2
]}

Buijnink, Joshua ^{[4
]}

van Dijk, Evert ^{[4
]}

Izumiya, Yoshihiro ^{[5
,6
,7
]}

Kung, Hsing-jien ^{[7
]}

Temple, Brenda R. S. ^{[8
,9
,10
]}

Damania, Blossom ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Gene Therapy Ctr, Chapel Hill, NC 27599 USA

[4] Pepscan Presto BV, NL-8243 Lelystad, Netherlands

[5] Univ Calif Davis, Sch Med, Dept Dermatol, Sacramento, CA 95817 USA

[6] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95817 USA

[7] Univ Calif Davis, Ctr Comprehens Canc, Sacramento, CA 95817 USA

[8] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[9] Univ N Carolina, RL Juliano Struct Bioinformat Core Facil, Chapel Hill, NC 27599 USA

[10] Univ N Carolina, Struct Biol Ctr, Chapel Hill, NC 27599 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2016年 / 113卷 / 28期

关键词：

cell signaling; viral protein kinase; S6K; KSHV; ORF36; SARCOMA-ASSOCIATED-HERPESVIRUS; PROTEIN-KINASE; PHOSPHORYLATION; REACTIVATION; MAINTENANCE; INHIBITION; GLYCOLYSIS; ACTIVATION; EXPRESSION; AUTOCRINE;

D O I：

10.1073/pnas.1600587113

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi's sarcoma-associated herpesvirus (KSHV) enhances protein synthesis by mimicking the function of the cellular protein S6 kinase (S6KB1). Similar to S6KB1, vPK phosphorylates the ribosomal S6 protein and up-regulates global protein synthesis. vPK also augments cellular proliferation and anchorage-independent growth. Furthermore, we report that both vPK and S6KB1 phosphorylate the enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) and that both kinases promote endothelial capillary tubule formation.

引用

页码：7876 / 7881

页数：6

共 40 条

[1] Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma
Bhatt, Aadra P.
Jacobs, Sarah R.
Freemerman, Alex J.
Makowski, Liza
Rathmell, Jeffrey C.
Dittmer, Dirk P.
Damania, Blossom
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (29) : 11818 - 11823
[2] Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas
Bhatt, Aadra P.
Bhende, Prasanna M.
Sin, Sang-Hoon
Roy, Debasmita
Dittmer, Dirk P.
Damania, Blossom
[J]. BLOOD, 2010, 115 (22) : 4455 - 4463
[3] Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi's sarcoma-associated herpesvirus-infected cells
Davis, David A.
Singer, Kathleen E.
Reynolds, Irene P.
Haque, Muzarnmel
Yarchoan, Robert
[J]. CANCER RESEARCH, 2007, 67 (14) : 7003 - 7010
[4] Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
De Bock, Katrien
Georgiadou, Maria
Schoors, Sandra
Kuchnio, Anna
Wong, Brian W.
Cantelmo, Anna Rita
Quaegebeur, Annelies
Ghesquiere, Bart
Cauwenberghs, Sandra
Eelen, Guy
Phng, Li-Kun
Betz, Inge
Tembuyser, Bieke
Brepoels, Katleen
Welti, Jonathan
Geudens, Ilse
Segura, Inmaculada
Cruys, Bert
Bifari, Franscesco
Decimo, Ilaria
Blanco, Raquel
Wyns, Sabine
Vangindertael, Jeroen
Rocha, Susana
Collins, Russel T.
Munck, Sebastian
Daelemans, Dirk
Imamura, Hiromi
Devlieger, Roland
Rider, Mark
Van Veldhoven, Paul P.
Schuit, Frans
Bartrons, Ramon
Hofkens, Johan
Fraisl, Peter
Telang, Sucheta
DeBerardinis, Ralph J.
Schoonjans, Luc
Vinckier, Stefan
Chesney, Jason
Gerhardt, Holger
Dewerchin, Mieke
Carmeliet, Peter
[J]. CELL, 2013, 154 (03) : 651 - 663
[5] Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells
Delgado, Tracie
Carroll, Patrick A.
Punjabi, Almira S.
Margineantu, Daciana
Hockenbery, David M.
Lagunoff, Michael
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (23) : 10696 - 10701
[6] Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells
Diks, SH
Kok, K
O'Toole, T
Hommes, DW
van Dijken, P
Joore, J
Peppelenbosch, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) : 49206 - 49213
[7] Tousled-like Kinases Modulate Reactivation of Gammaherpesviruses from Latency
Dillon, Patrick J.
Gregory, Sean M.
Tamburro, Kristen
Sanders, Marcia K.
Johnson, Gary L.
Raab-Traub, Nancy
Dittmer, Dirk P.
Damania, Blossom
[J]. CELL HOST & MICROBE, 2013, 13 (02) : 204 - 214
[8] Functions and regulation of the 70 kDa ribosomal S6 kinases
Fenton, Tim R.
Gout, Ivan T.
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2011, 43 (01) : 47 - 59
[9] KSHV: Pathways to Tumorigenesis and Persistent Infection
Giffin, Louise
Damania, Blossom
[J]. ADVANCES IN VIRUS RESEARCH, VOL 88, 2014, 88 : 111 - 159
[10] eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
Gingras, AC
Raught, B
Sonenberg, N
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 : 913 - 963

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