Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease

被引:10
作者
Aune, Susanne Kristine [1 ,2 ]
Cwikiel, Joanna [1 ]
Flaa, Arnljot [3 ]
Arnesen, Harald [1 ,2 ]
Solheim, Svein [1 ,3 ]
Awoyemi, Ayodeji [1 ,2 ]
Troseid, Marius [2 ,4 ]
Seljeflot, Ingebjorg [1 ,2 ,3 ]
Helseth, Ragnhild [1 ,3 ]
机构
[1] Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway
[2] Univ Oslo, Fac Med, N-0316 Oslo, Norway
[3] Oslo Univ Hosp Ulleval, Dept Cardiol, N-0424 Oslo, Norway
[4] Oslo Univ Hosp, Rikshosp, Sect Clin Immunol & Infect Dis, N-0424 Oslo, Norway
关键词
gut leakage; microbiota; cardiovascular disease; inflammation; acute exercise; strenuous exercise; ACUTE CARDIOVASCULAR EVENTS; PHYSICAL-ACTIVITY; SCIENTIFIC STATEMENT; EXPRESSION; INFLAMMATION; PERSPECTIVE; MEDIATORS; MONOCYTES; HEALTH; RISKS;
D O I
10.3390/cells10092193
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in response to a bout of strenuous exercise in patients with symptoms of CAD. Patients referred to exercise stress testing due to symptoms of CAD were included (n = 287). A maximal exercise ECG stress test was performed and venous blood samples were drawn at rest and within five minutes after, for analysis of soluble cluster of differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP), intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide (LPS) and gene expression of toll-like receptor 4 (TLR4) in circulating leukocytes. Patients then underwent coronary angiography. LPS, LBP and sCD14 increased significantly after strenuous exercise in patients with symptoms of CAD, suggesting that even short bouts of vigorous exercise are associated with gut leakage. The gene expression of TLR4 decreased significantly after exercise, possibly as a negative feedback to the increase in LPS. There were no differences in exercise-induced changes between the groups of CAD, suggesting gut leakage to be independent of the presence of CAD.
引用
收藏
页数:11
相关论文
共 33 条
[31]  
Zarember KA, 2002, J IMMUNOL, V168, P554, DOI 10.4049/jimmunol.168.2.554
[32]   Dysbiosis signatures of gut microbiota in coronary artery disease [J].
Zhu, Qi ;
Gao, Renyuan ;
Zhang, Yi ;
Pan, Dengdeng ;
Zhu, Yefei ;
Zhang, Xiaohui ;
Yang, Rong ;
Jiang, Rong ;
Xu, Yawei ;
Qin, Huanlong .
PHYSIOLOGICAL GENOMICS, 2018, 50 (10) :893-903
[33]   Exercise regulation of intestinal tight junction proteins [J].
Zuhl, Micah ;
Schneider, Suzanne ;
Lanphere, Katherine ;
Conn, Carole ;
Dokladny, Karol ;
Moseley, Pope .
BRITISH JOURNAL OF SPORTS MEDICINE, 2014, 48 (12) :980-+