Pathogenesis and inflammatory responses of swine H1N2 influenza viruses in pigs

被引：26

作者：

Jo, Su Kyoung ^{[1
]}

Kim, Hyun Soo ^{[1
]}

Cho, Sung Whan ^{[1
]}

Seo, Sang Heui ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Vet Med, Div Prevent Med, Lab Influenza Res, Taejon 305764, South Korea

来源：

VIRUS RESEARCH | 2007年 / 129卷 / 01期

关键词：

cytokine; influenza virus; pig;

D O I：

10.1016/j.virusres.2007.05.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Swine influenza viruses are an important pathogen in pig industry. In this study, we wanted to know whether swine H1N2 influenza viruses circulating in Korean pigs would cause clinical signs in pigs when experimentally infected. When pigs were infected with swine H1N2 viruses isolated from Korean pigs, pigs suffered from severe clinical signs of coughing, nasal discharge, labored breathing, facial edema, anorexia, and diarrhea. When the level of cytokine induction was measured using lung tissues, pro-inflammatory cytokines such as TNF-alpha, IL-1, and IL-8 were induced higher in lungs of infected pigs than in lungs of uninfected pigs. However, no increased induction of the anti-inflammatory cytokines such as IL-4 and IL-10 was observed in lungs of infected pigs. These results suggest that the pathogenesis induced in pigs by H1N2 influenza viruses may be induced by pro-inflammatory cytokines instead of anti-inflammatory cytokines. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：64 / 70

页数：7

共 30 条

[1] Release of macrophage migration inhibitory factor and CXCL8/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection [J].