Flow Cytometry

被引：13
作者：
Gascue, Amaia [1 ]
Merino, Juana [1 ]
Paiva, Bruno [1 ,2 ,3 ,4 ]
机构：
[1] Clin Univ Navarra, Dept Immunol, Av Pio 12,36, Pamplona 31008, Spain
[2] Ctr Appl Med Res CIMA, Av Pio 12 55, Pamplona 31008, Spain
[3] Healthcare Res Inst Navarre IDISNA, Pamplona, Spain
[4] CIBERONC, Madrid, Spain
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 05期
关键词：
Waldenstrom macroglobulinemia; Flow cytometry; Immunophenotyping; B cells; Plasma cells; IGM MONOCLONAL GAMMOPATHY; MINIMAL RESIDUAL DISEASE; MYELOMA PLASMA-CELLS; WALDENSTROMS MACROGLOBULINEMIA; DIFFERENTIAL-DIAGNOSIS; RESPONSE ASSESSMENT; MULTIPLE-MYELOMA; IDENTIFICATION; PROGRESSION; LYMPHOMA;
D O I：
10.1016/j.hoc.2018.05.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Multiparameter flow cytometry (MFC) is valuable in the diagnosis and monitoring of most hematologic malignancies. Although the assessment of cellular infiltrates in Waldenstrom macroglobulinemia (WM) relies on morphology and immunohistochemistry grounds, there is evidence pointing to the clinical significance of MFC in this disease. Herein, the authors review immunophenotypic patterns of B-cell development, the antigen profile of the WM clone and its normal B-cell counterpart, the clinical applicability of MFC in the differential diagnosis of immunoglobulin M-secreting lymphoproliferative disorders and monoclonal gammopathies, and its potential role in detecting minimal residual disease and monitoring treatment efficacy in WM.
引用
收藏
页码：765 / +
页数：13
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