The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats

被引：32
|
作者：
Shi, Min [1 ,2 ]
Cui, Fang [1 ]
Liu, Ai-Jing [3 ]
Ma, Hui-Jie [1 ]
Cheng, Ming [1 ]
Song, Shu-Xia [4 ]
Yuan, Fang [1 ]
Li, De-Pei [5 ]
Zhang, Yi [1 ,6 ,7 ]
机构：
[1] Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Peoples R China
[2] Hebei Med Univ, Hosp 2, Dept Clin Lab, Shijiazhuang 050017, Peoples R China
[3] Hebei Med Univ, Hosp 2, Dept Immune & Rheumatism, Shijiazhuang 050017, Peoples R China
[4] Hebei Med Univ, Dept Immunol, Shijiazhuang 050017, Peoples R China
[5] Univ Texas MD Anderson Canc Ctr, Dept Crit Care, Houston, TX 77030 USA
[6] Hebei Key Lab Med Biotechnol, Shijiazhuang 050017, Peoples R China
[7] Hebei Collaborat Innovat Ctr Cardio Cerebrovasc D, Shijiazhuang 050000, Hebei, Peoples R China
来源：
JOURNAL OF INFLAMMATION-LONDON | 2015年 / 12卷
基金：
中国国家自然科学基金;
关键词：
Chronic intermittent hypobaric hypoxia; Rheumatoid arthritis; T lymphocytes; Th1/Th2; HIF-1; alpha; NF-kappa B; Rat; TUMOR-NECROSIS-FACTOR; FACTOR-KAPPA-B; INDUCIBLE FACTOR; RHEUMATOID-ARTHRITIS; FACTOR-ALPHA; CYTOKINES; ROLES; IL-17; INFLAMMATION; EXPRESSION;
D O I：
10.1186/s12950-015-0068-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective: To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat. Methods: Fifty-four adult male Sprague-Dawley rats were used in the experiment. Arthritis in CIA rats (n=18) was induced by injection of collagen. The CIHH+CIA rats (n=18) were treated with CIHH (simulated 3000 m altitude, 5 hours per day for 28 days, PO2=108.8 mmHg) before CIA. The control rats (n=18) were not given any treatment. Results: (1) Incidence rate of CIA in CIHH+CIA rats was significantly lower than that in CIA rats (P<0.05). (2) The paw thickness and arthritis index (AI) value in CIHH+CIA rats were lower than those in CIA rats (P<0.05). (3) The hyperplasia with inflammatory infiltration in synovial tissue of joints in CIHH+CIA rats was much alleviative compared with CIA rats. (4) TNF-alpha, IFN-gamma, IL-4 and IL-17 in synovial tissue of joint and serum in CIHH+CIA rats were decreased compared with CIA rats (P<0.05). (5) The number of CD4-positive T-lymphocytes and the ratio of CD4/CD8 T-lymphocytes in peripheral blood in CIHH+CIA rats were lower than those in CIA rats (P<0.05). (6) The protein expression of HIF-1 alpha and NF-kappa B in synovial tissue of joint in CIHH+CIA rats was decreased compared with CIA rats (P<0.05). Conclusion: CIHH pretreatment has a protective effect against collagen-induced arthritis in rat through down-regulation of HIF-1 alpha and NF-kappa B, inhibition of inflammatory cytokines TNF-alpha and IL-17, and balance in CD4/CD8 and Th1/Th2 T lymphocytes.
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页数：9
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