New iridoids from the roots of Valeriana dioscoridis Sm.

被引：26

作者：

Kirmizibekmez, Hasan ^{[1
]}

Kusz, Norbert ^{[2
]}

Berdi, Peter ^{[3
]}

Zupko, Istvan ^{[3
,4
]}

Hohmann, Judit ^{[2
,4
]}

机构：

[1] Yeditepe Univ, Dept Pharmacognosy, Fac Pharm, TR-34755 Istanbul, Turkey

[2] Univ Szeged, Dept Pharmacognosy, Fac Pharm, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Pharmacodynam & Biopharm, Fac Pharm, H-6720 Szeged, Hungary

[4] Univ Szeged, Interdisciplinary Ctr Nat Prod, H-6720 Szeged, Hungary

来源：

FITOTERAPIA | 2018年 / 130卷

关键词：

Valeriana dioscoridis; Caprifoliaceae; Iridoids; Bis-iridoid glycoside; Antiproliferative activity; ACYLATED IRIDOIDS; AERIAL PARTS; JATAMANSI; GLUCOSIDES; GLYCOSIDES; EBULUS; ACID; OIL;

D O I：

10.1016/j.fitote.2018.08.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new iridoids (1-4), together with three known iridoids (5-7), one known flavonoid glycoside, three phenolic acids and one phytosterol were isolated from the roots of Valeriana dioscoridis. Their structures were elucidated by means of NMR spectroscopy and mass spectrometry. This is the first report on the phytochemical composition of the non-volatile constituents of V. dioscoridis and the occurrence of a bis-iridoid glycoside in the genus Valeriana. The antiproliferative effects of the iridoids (1-7) were evaluated against three human cancer cell lines of gynacological origin (HeLa, A2780 and T47D) at 10, 30 and 60 mu M concentrations, using the MTT assay and they elicited modest antiproliferative activity when compared to the reference agent, cisplatin.

引用

页码：73 / 78

页数：6

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