HALICHONADINS M-Q, SESQUITERPENES FROM AN OKINAWAN MARINE SPONGE HALICHONDRIA SP.

被引：11

作者：

Tanaka, Naonobu ^{[1
]}

Suto, Shohei ^{[1
]}

Asai, Miki ^{[1
]}

Kusama, Taishi ^{[1
]}

Takahashi-Nakaguchi, Azusa ^{[2
]}

Gonoi, Tohru ^{[2
]}

Fromont, Jane ^{[3
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Med Mycol Res Ctr, Chiba 2608673, Japan

[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

HETEROCYCLES | 2015年 / 90卷 / 01期

关键词：

Marine Sponge; Helichondria sp; Sesquiterpene; Halichonadins M-Q; NATURAL-PRODUCTS;

D O I：

10.3987/COM-14-S(K)2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new dimeric sesquiterpenes, halichonadins M-P (1-4), and one new sesquiterpene, halichonadin Q (5), were isolated from an Okinawan marine sponge Halichondria sp. The sesquiterpenes have eudesmane skeleton in common Halichonadin M (1) is a symmetrical dimer linked to a nitrilotriacetic acid fragment through amide bonds. Halichonadin N (2) is a structurally unique dimeric sesquiterpene connected via a pyrrolidine unit, while halichonadins 0 (3) and P (4) have linker moieties consisting of a piperidine unit. Halichonadin Q (5) is a sesquiterpene possessing a pyrrolidine unit. The structures of 1-5 were elucidated by spectroscopic analysis. Halichonadin 0 (3) showed antimicrobial activity against Staphylococcus aureus, Micrococcus luteus, and Trichophyton mentagrophytes.

引用

页码：173 / 185

页数：13

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