Medical Progress: Profound Deafness in Childhood.

被引：285
作者：
Kral, Andrej [1 ,2 ,3 ]
O'Donoghue, Gerard M. [4 ,5 ]
机构：
[1] Hannover Med Sch, Inst Audioneurotechnol, D-30625 Hannover, Germany
[2] Hannover Med Sch, Dept Expt Otol Ear Nose & Throat Clin, D-30625 Hannover, Germany
[3] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA
[4] Natl Inst Hlth Res Nottingham, Natl Biomed Res Unit Hearing, Nottingham, England
[5] Nottingham Univ Hosp Natl Hlth Serv Trust, Queens Med Ctr, Dept Otolaryngol, Nottingham, England
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 363卷 / 15期
关键词：
SHORT-TERM-MEMORY; COCHLEAR IMPLANTS; CORTICAL REORGANIZATION; ELECTRICAL-STIMULATION; LANGUAGE-DEVELOPMENT; SPEECH-PERCEPTION; CHILDREN; HEARING; AGE; DEPRIVATION;
D O I：
10.1056/NEJMra0911225
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Profound childhood deafness is not just a sensory loss but has a lifelong effect on many levels of brain function. Many developments are transforming the management of profound deafness; these include universal neonatal screening, early intervention, and advances in diagnostic neuroaudiology, molecular biology, and integrative neuroscience. Cochlear implantation has transformed developmental outcomes, providing access to spoken language for the majority of children who receive implants early in life. Laboratory investigations have elaborated the neurobiologic processes that follow auditory deprivation, particularly a physiological uncoupling of the auditory system, resulting in degradation of its functional connectivity with key centers in the brain. Copyright © 2010 Massachusetts Medical Society. All rights reserved.
引用
收藏
页码：1438 / 1450
页数：13
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