Enantiomeric separation of amphetamine by high-performance liquid chromatography using chiral crown ether-coated reversed-phase packing: Application to forensic analysis

被引：22
作者：
Makino, Y
Ohta, S
Hirobe, M
机构：
[1] UNIV TOKYO,FAC MED,BUNKYO KU,TOKYO 113,JAPAN
[2] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN
来源：
FORENSIC SCIENCE INTERNATIONAL | 1996年 / 78卷 / 01期
关键词：
amphetamine; high-performance liquid chromatography; chiral crown ether column; norephedrine; optical resolution; primary amine;
D O I：
10.1016/0379-0738(95)01865-4
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
d-Amphetamine and l-amphetamine were clearly separated by HPLC analysis using a chiral crown ether column (CROWNPACK CR(+)). As little as 0.1% d-amphetamine in bulk methamphetamine could be determined. The enantiomeric form of the by-product in a drug sample may be helpful in evaluating thr possibility of illicit synthesis. When the isomeric composition of amphetamine present in urine from a methamphetamine abuser was examined, only d-amphetamine was detected as a metabolite. The present method was also applied to the enantiomeric separation of norephedrine.
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页码：65 / 70
页数：6
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