microRNAs in ischaemic cardiovascular diseases

被引：7
作者：
Greco, Simona [1 ]
Zaccagnini, Germana [1 ]
Voellenkle, Christine [1 ]
Martelli, Fabio [1 ]
机构：
[1] IRCCS Policlin San Donato, Mol Cardiol Lab, Via Morandi 30, I-20097 Milan, Italy
来源：
EUROPEAN HEART JOURNAL SUPPLEMENTS | 2016年 / 18卷 / 0E期
关键词：
microRNA; Cardiovascular diseases; Ischaemia; Hypoxia; MODULATES TISSUE-RESPONSE; ENDOTHELIAL GROWTH-FACTOR; HEART-FAILURE PATIENTS; MYOCARDIAL-INFARCTION; CIRCULATING MICRORNAS; TARGET IDENTIFICATION; CARDIAC FIBROSIS; HYPOXIA; MIR-210; EXPRESSION;
D O I：
10.1093/eurheartj/suw012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.
引用
收藏
页码：E31 / E36
页数：6
相关论文
共 58 条
  • [1] Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD34+cells enhances cell-mediated angiogenesis
    Alaiti, Mohamad Amer
    Ishikawa, Masakazu
    Masuda, Haruchika
    Simon, Daniel I.
    Jain, Mukesh K.
    Asahara, Takayuki
    Costa, Marco A.
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (10) : 2413 - 2421
  • [2] [Anonymous], 2015, J MOL CELL CARDIOL, DOI [DOI 10.1016/j.yjmcc.2015.01.011, DOI 10.1016/J.YJMCC.2015.01.011]
  • [3] MicroRNAs: Target Recognition and Regulatory Functions
    Bartel, David P.
    [J]. CELL, 2009, 136 (02) : 215 - 233
  • [4] MicroRNA Target Identification: Lessons from HypoxamiRs
    Bertero, Thomas
    Robbe-Sermesant, Karine
    Le Brigand, Kevin
    Ponzio, Gilles
    Pottier, Nicolas
    Rezzonico, Roger
    Mazure, Nathalie M.
    Barbry, Pascal
    Mari, Bernard
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2014, 21 (08) : 1249 - 1268
  • [5] Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
    Biswas, Sabyasachi
    Roy, Sashwati
    Banerjee, Jaideep
    Hussain, Syed-Rehan A.
    Khanna, Savita
    Meenakshisundaram, Guruguhan
    Kuppusamy, Periannan
    Friedman, Avner
    Sen, Chandan K.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (15) : 6976 - 6981
  • [6] MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice
    Bonauer, Angelika
    Carmona, Guillaume
    Iwasaki, Masayoshi
    Mione, Marina
    Koyanagi, Masamichi
    Fischer, Ariane
    Burchfield, Jana
    Fox, Henrik
    Doebele, Carmen
    Ohtani, Kisho
    Chavakis, Emmanouil
    Potente, Michael
    Tjwa, Marc
    Urbich, Carmen
    Zeiher, Andreas M.
    Dimmeler, Stefanie
    [J]. SCIENCE, 2009, 324 (5935) : 1710 - 1713
  • [7] Bostjancic E, 2010, FOLIA BIOL-PRAGUE, V56, P27
  • [8] MicroRNA microarray expression profiling in human myocardial infarction
    Bostjancic, Emanuela
    Zidar, Nina
    Glavac, Damjan
    [J]. DISEASE MARKERS, 2009, 27 (06) : 255 - 268
  • [9] Deregulation of microRNA-503 Contributes to Diabetes Mellitus-Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia
    Caporali, Andrea
    Meloni, Marco
    Voellenkle, Christine
    Bonci, Desiree
    Sala-Newby, Graciela B.
    Addis, Roberta
    Spinetti, Gaia
    Losa, Sergio
    Masson, Rachel
    Baker, Andrew H.
    Agami, Reuven
    le Sage, Carlos
    Condorelli, Gianluigi
    Madeddu, Paolo
    Martelli, Fabio
    Emanueli, Costanza
    [J]. CIRCULATION, 2011, 123 (03) : 282 - U117
  • [10] Role for MicroRNA-21 in Atrial Profibrillatory Fibrotic Remodeling Associated With Experimental Postinfarction Heart Failure
    Cardin, Sophie
    Guasch, Eduard
    Luo, Xiaobin
    Naud, Patrice
    Khai Le Quang
    Shi, YanFen
    Tardif, Jean-Claude
    Comtois, Philippe
    Nattel, Stanley
    [J]. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2012, 5 (05) : 1027 - 1035
123456