Random genetic drift determines the level of mutant mtDNA in human primary oocytes

被引：121
作者：
Brown, DT
Samuels, DC
Michael, EM
Turnbull, DM
Chinnery, PF [1 ]
机构：
[1] Newcastle Univ, Dept Neurol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[2] Newcastle Univ, Dept Math, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[3] Newcastle Univ, Dept Obstet & Gynaecol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 2001年 / 68卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1086/318190
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.
引用
收藏
页码：533 / 536
页数：4
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