Group 2 Innate Lymphoid Cells in Human Respiratory Disorders

被引：36

作者：

van der Ploeg, Esmee K. ^{[1
,2
]}

Mascaro, Ana Carreras ^{[3
]}

Huylebroeck, Danny ^{[1
]}

Hendriks, Rudi W. ^{[2
]}

Stadhouders, Ralph ^{[1
,2
]}

机构：

[1] Erasmus MC, Dept Cell Biol, Rotterdam, Netherlands

[2] Erasmus MC, Dept Pulm Med, Rotterdam, Netherlands

[3] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

来源：

JOURNAL OF INNATE IMMUNITY | 2020年 / 12卷 / 01期

关键词：

Innate lymphoid cell; ILC2; Plasticity; Asthma; Allergy; Lung; TRANSCRIPTION FACTOR GATA3; TYPE-2; IMMUNE-RESPONSE; CHRONIC RHINOSINUSITIS; AIRWAY INFLAMMATION; CHEMOSENSORY CELLS; CRITICAL REGULATOR; LUNG INFLAMMATION; ALLERGIC RHINITIS; PERIPHERAL-BLOOD; NASAL POLYPS;

D O I：

10.1159/000496212

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with type-2 immunity. In addition, progress has also been made in translating these findings from animal studies into a context of human immunity. Importantly, recent observations strongly support a role for ILC2s in several diseases of the human respiratory system. However, many aspects of human ILC2 biology are still unclear, including how these cells develop and which signals control their activity. As a result, the exact role played by ILCs in human health and disease remains poorly understood. Here, we summarize our current understanding of human ILC2 biology and focus on their potential involvement in various human respiratory disorders. (c) 2018 The Author(s) Published by S. Karger AG, Basel

引用

页码：47 / 62

页数：16

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