High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

被引：12

作者：

Kritchenkov, Andreii S. ^{[1
,2
]}

Kurasova, Margarita N. ^{[1
]}

Godzishevskaya, Anastasia A. ^{[1
]}

Mitrofanova, Elizaveta S. ^{[1
]}

Egorov, Anton R. ^{[1
]}

Yagafarov, Niyaz Z. ^{[1
,3
]}

Meza, Moises J. Ballesteros ^{[1
]}

Tskhovrebov, Alexander G. ^{[1
]}

Artemjev, Alexey A. ^{[1
]}

Andrusenko, Elena, V ^{[4
]}

Khrustalev, Victor N. ^{[1
,5
]}

机构：

[1] Peoples Friendship Univ Russia, RUDN Univ, Moscow 117198, Russia

[2] Natl Acad Sci Belarus, Inst Tech Acoust, Vitebsk 210009, BELARUS

[3] NI Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia

[4] Altay State Univ, Inst Chem & Chem & Pharmaceut Technol, Dept Chem, Barnaul 656049, Russia

[5] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

MENDELEEV COMMUNICATIONS | 2021年 / 31卷 / 04期

关键词：

chitosan; pyridoxal; nanoparticles; antibacterial activity;

D O I：

10.1016/j.mencom.2021.07.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin.

引用

页码：504 / 506

页数：3

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