Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909

被引：13

作者：

Chen, Minghua ^{[1
,2
]}

Wu, Yexiang ^{[1
,2
]}

He, Yi ^{[3
,4
]}

Xu, Yanni ^{[1
,2
]}

Li, Yongzhen ^{[1
,2
]}

Li, Dongsheng ^{[1
,2
]}

Feng, Tingting ^{[1
,2
]}

Yu, Liyan ^{[1
,2
]}

Hong, Bin ^{[1
,2
]}

Jiang, Wei ^{[1
,2
]}

Si, Shuyi ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Informat Ctr, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100730, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 03期

关键词：

Atherosclerosis; Human high density lipoprotein receptor; Streptomyces sp; Trichostatin analogues; HIGH-DENSITY-LIPOPROTEIN; RECEPTOR SR-BI; HEART-DISEASE; UP-REGULATOR; METABOLISM; BINDING; ANALOG; ESTER; RAT;

D O I：

10.1016/j.bmcl.2014.12.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new trichostatin analogues (1-4) and six known analogues have been isolated from the rice fermentation of the Streptomyces sp. CPCC 203909. The structures and absolute configurations of these compounds were determined by extensive spectroscopic analysis including 2D NMR and electronic circular dichroism (ECD) calculations based on the quantum-mechanical time-dependent density functional theory (TDDFT). Compounds 2, 5-7, 9, and 10 up-regulated the transcriptional activity of human high density lipoprotein receptor (CLA-1) with EC50 values of 0.38-78.83 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：562 / 565

页数：4

共 21 条

[1] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].