Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

被引：2760
作者：
Knop, Katrin [1 ,3 ]
Hoogenboom, Richard [2 ,3 ]
Fischer, Dagmar [4 ]
Schubert, Ulrich S. [1 ,2 ,3 ]
机构：
[1] Univ Jena, LOMC, D-07745 Jena, Germany
[2] Eindhoven Univ Technol, Lab Macromol Chem & Nanosci, NL-5600 MB Eindhoven, Netherlands
[3] DPI, NL-5600 AX Eindhoven, Netherlands
[4] Univ Jena, Dept Pharmaceut Technol, D-07745 Jena, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 36期
关键词：
drug delivery; nanotechnology; poly(ethylene glycol); polymers; stealth effect; ACCELERATED BLOOD CLEARANCE; LOW-MOLECULAR-WEIGHT; AMPHIPHILIC DIBLOCK COPOLYMER; ALLERGIC CONTACT-DERMATITIS; RING-OPENING POLYMERIZATION; WATER-SOLUBLE POLYMERS; POLYETHYLENE-GLYCOL; COMPLEMENT ACTIVATION; RADICAL POLYMERIZATION; PEGYLATED LIPOSOMES;
D O I：
10.1002/anie.200902672
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
All-round talent PEG? Poly(ethylene glycol) (PEG) surrounds us in our everyday lives and, particularly in drug-delivery applications, counts as a gold standard. This omnipresent polymer is explored from different angles-advantages and disadvantages are evaluated together with alternative polymers. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6288 / 6308
页数：21
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