Treatment of symptomatic primary biliary cirrhosis with lymphocytapheresis: a preliminary clinical trial

被引：0

作者：

Ichida, T ^{[1
]}

Sato, K ^{[1
]}

Uchida, M ^{[1
]}

Yamagiwa, S ^{[1
]}

Yonekura, K ^{[1
]}

Sugimura, K ^{[1
]}

Sugahara, S ^{[1
]}

Ishihara, K ^{[1
]}

Asakura, H ^{[1
]}

机构：

[1] Niigata Univ, Sch Med, Dept Internal Med 3, Niigata 951, Japan

来源：

HEPATOLOGY RESEARCH | 1998年 / 11卷 / 01期

关键词：

liver infiltrating lymphocyte; lymphocytapheresis; NK cell; primary biliary cirrhosis;

D O I：

10.1016/S1386-6346(98)00009-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Lymphocytapheresis was carried out as a preliminary clinical trial for four patients with symptomatic primary biliary cirrhosis (PBC). After lymphocytapheresis, severe itching disappeared in two patients and jaundice improved or disappeared in all cases. Serum levels of total bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase and transaminase were decreased after the treatment. In liver tissue, the number of infiltrated lymphocytes was slightly decreased in both the parenchyma and portal tract. Increased CD3(-)CD56(+) lymphocytes (NK cells) in the liver were dramatically diminished after the treatment. CD3(+)CD56(-) lymphocytes (T cells), especially CD8(+) lymphocytes and CD56(+) T lymphocytes, were increased after the treatment in two cases. Although these results are preliminary and based on only a small number of patients and over short observation periods, lymphocytapheresis might be a useful therapeutic tool for patients with advanced PBC, giving excellent improvement of symptoms and results of liver function tests. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 48

页数：8

共 19 条

[1]

AMANO K, 1991, THERAPEUTIC PLASMAPH, V9, P423

[2] EVALUATION OF COLCHICINE THERAPY IN PRIMARY BILIARY-CIRRHOSIS [J].

BODENHEIMER, H ;

SCHAFFNER, F ;

PEZZULLO, J .

GASTROENTEROLOGY, 1988, 95 (01) :124-129

[3] BENEFICIAL EFFECT OF AZATHIOPRINE AND PREDICTION OF PROGNOSIS IN PRIMARY BILIARY-CIRRHOSIS - FINAL RESULTS OF AN INTERNATIONAL TRIAL [J].

CHRISTENSEN, E ;

NEUBERGER, J ;

CROWE, J ;

ALTMAN, DG ;

POPPER, H ;

PORTMANN, B ;

DONIACH, D ;

RANEK, L ;

TYGSTRUP, N ;

WILLIAMS, R .

GASTROENTEROLOGY, 1985, 89 (05) :1084-1091

[4] TRANSPLANTATION FOR PRIMARY BILIARY-CIRRHOSIS [J].

ESQUIVEL, CO ;

VANTHIEL, DH ;

DEMETRIS, AJ ;

BERNARDOS, A ;

IWATSUKI, S ;

MARKUS, B ;

GORDON, RD ;

MARSH, JW ;

MAKOWKA, L ;

TZAKIS, AG ;

TODO, S ;

GAVALER, JS ;

STARZL, TE .

GASTROENTEROLOGY, 1988, 94 (05) :1207-1216

[5]

HATA K, 1991, HEPATOLOGY, V14, P495, DOI 10.1016/0270-9139(91)90189-3

[6]

HISATSUNE T, 1995, J IMMUNOL, V154, P88

[7] RANDOMIZED TRIAL OF CHLORAMBUCIL FOR PRIMARY BILIARY-CIRRHOSIS [J].

HOOFNAGLE, JH ;

DAVIS, GL ;

SCHAFER, DF ;

PETERS, M ;

AVIGAN, MI ;

PAPPAS, SC ;

HANSON, RG ;

MINUK, GY ;

DUSHEIKO, GM ;

CAMPBELL, G ;

MACSWEEN, RNM ;

JONES, EA .

GASTROENTEROLOGY, 1986, 91 (06) :1327-1334

[8] LIVING RELATED-DONOR LIVER-TRANSPLANTATION FROM ADULT TO ADULT FOR PRIMARY BILIARY-CIRRHOSIS [J].

ICHIDA, T ;

MATSUNAMI, H ;

KAWASAKI, S ;

MAKUUCHI, M ;

HARADA, T ;

ITOH, S ;

ASAKURA, H .

ANNALS OF INTERNAL MEDICINE, 1995, 122 (04) :275-276

[9] Medical progress - Primary biliary cirrhosis [J].

Kaplan, MM .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (21) :1570-1580

[10] PILOT-STUDY OF CYCLOSPORIN-A IN PATIENTS WITH SYMPTOMATIC PRIMARY BILIARY-CIRRHOSIS [J].

MINUK, GY ;

BOHME, CE ;

BURGESS, E ;

HERSHFIELD, NB ;

KELLY, JK ;

SHAFFER, EA ;

SUTHERLAND, LR ;

VANROSENDAAL, G .

GASTROENTEROLOGY, 1988, 95 (05) :1356-1363

← 1 2 →