Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation

被引：73

作者：

Brager, DH ^{[1
]}

Cai, X ^{[1
]}

Thompson, SM ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 06期

关键词：

D O I：

10.1038/nn1067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases(1-3). Exogenous protein kinase activators increase release probability at several mammalian CNS synapses(4-6), but the physiological conditions under which presynaptic protein kinases become activated are not known. We report here that calcium/phospholipid-dependent protein kinase C (PKC) is activated by high-frequency stimulation and mediates post-tetanic potentiation (PTP) in the rat hippocampus.

引用

页码：551 / 552

页数：2

共 15 条

[1] AKERS RF, 1987, J NEUROSCI, V7, P3976
[2] Short-term synaptic plasticity, simulation of nerve terminal dynamics, and the effects of protein kinase C activation in rat hippocampus
Brager, DH
Capogna, M
Thompson, SM
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 2002, 541 (02): : 545 - 559
[3] Excitatory synaptic transmission and its modulation by PKC is unchanged in the hippocampus of GAP-43-deficient mice
Capogna, M
Fankhauser, C
Gagliardini, V
Gähwiler, BH
Thompson, SM
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (02) : 433 - 440
[4] CAPOGNA M, 1995, J NEUROSCI, V15, P1249
[5] DELANEY KR, 1989, J NEUROSCI, V9, P3558
[6] Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C - Its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin
Fujita, Y
Sasaki, T
Fukui, K
Kotani, H
Kimura, T
Hata, Y
Sudhof, TC
Scheller, RH
Takai, Y
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) : 7265 - 7268
[7] DUAL EFFECT OF REPETITIVE STIMULATION ON POST-TETANIC POTENTIATION OF TRANSMITTER RELEASE AT FROG NEUROMUSCULAR-JUNCTION
MAGLEBY, KL
ZENGEL, JE
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1975, 245 (01): : 163 - 182
[8] POTENTIATION OF SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS BY PHORBOL ESTERS
MALENKA, RC
MADISON, DV
NICOLL, RA
[J]. NATURE, 1986, 321 (6066) : 175 - 177
[9] NIELANDER HB, 1995, J NEUROCHEM, V65, P1712
[10] REGEHR WG, 1994, J NEUROSCI, V14, P523

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