Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series

被引：12

作者：

Benmohammed, Abdelmadjid ^{[1
,2
,4
]}

Rekiba, Nawel ^{[2
,3
]}

Sehanine, Yassine ^{[3
]}

Louail, Ahmed Amine ^{[3
]}

Khoumeri, Omar ^{[4
]}

Kadiri, Mokhtaria ^{[2
]}

Djafri, Ayada ^{[2
]}

Terme, Thierry ^{[4
]}

Vanelle, Patrice ^{[4
]}

机构：

[1] Univ Mascara, Fac Exact Sci, Dept Chem, Mascara, Algeria

[2] Univ Oran1 Ahmed Ben Bella, Fac Sci Exactes & Appl, Dept Chim, Lab Synth Organ Appl LSOA, BP 1524 El Mnaouer, Oran, Algeria

[3] Hop Mil Reg Univ DOran Dr Amir Mohamed Benaissa, Unite Microbiol, Lab Cent, BP 35 Ahmed Medeghri, Oran, Algeria

[4] Aix Marseille Univ, Fac Pharm, ICR Inst Chim Radicalaire, Lab PharmacoChim Radicalaire,CNRS,UMR 7273, 27 Blvd Jean Moulin,CS 30064, F-13385 Marseille 05, France

来源：

MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 08期

关键词：

Indoles; Thiosemicarbazones; Thiazolidinones; Nucleophilic addition; Heterocycles; Antibacterial activity; BIOLOGICAL EVALUATION; IN-VITRO; 4-THIAZOLIDINONE DERIVATIVES; DESIGN; POTENT; INHIBITORS; MOIETY; AGENTS; RING;

D O I：

10.1007/s00706-021-02823-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency. [GRAPHICS] .

引用

页码：977 / 986

页数：10

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