Rituximab therapy in rheumatoid arthritis in daily practice

被引：0

作者：

Assous, Noemie ^{[1
]}

Gossec, Laure ^{[2
]}

Dieude, Phillippe ^{[3
]}

Meyer, Olivier ^{[3
]}

Dougados, Maxime ^{[2
]}

Kahan, Andre ^{[1
]}

Allanore, Yannick ^{[1
]}

机构：

[1] Paris Descartes Univ, Serv Rhumatol A, Hop Cochin, Dept Rheumatol A,Med Fac,AP HP, F-75014 Paris, France

[2] Paris Descartes Univ, Hop Cochin, Dept Rheumatol B, Med Fac,AP HP, F-75014 Paris, France

[3] Univ Paris 07, Dept Rheumatol, AP HP, F-75221 Paris, France

来源：

JOURNAL OF RHEUMATOLOGY | 2008年 / 35卷 / 01期

关键词：

rituximab; rheumatoid arthritis; open-label trial;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Rituximab has been shown to be effective in refractory rheumatoid arthritis (RA) in randomized controlled trials, allowing approval by health agencies. Our aim was to assess in routine care the effects of rituximab in patients with RA who had experienced an inadequate response to anti-tumor necrosis factor-alpha (TNF-alpha) agents or had a contraindication to these drugs. Methods. An observational retrospective study was conducted. Rituximab (1000 mg intravenous infusion on Days 1 and 15) was administered with concomitant methotrexate therapy. Responses defined according to the European League Against Rheumatism (EULAR criteria) were assessed at Week 24. Results. Fifty patients were included: 30 had inadequate response to anti-TNF-alpha and 20 had contraindication to anti-TNF-a drugs. EULAR response was observed in 82%, good response in 36% (including remission in 12%), moderate response in 46%, and no response in 18%. One infusion-related reaction and 2 pulmonary infections occurred. Eleven of the 50 patients (22%) experienced flare and received retreatment with rituximab at 6 months. Thirty additional patients had flare after 6 months and the median delay for retreatment among the 41 responders was 9 (range 6-24) months. No difference regarding efficacy or tolerance of rituximab was observed according to previous inadequate response or contraindication to anti-TNF. Conclusion. A single cycle of rituximab, in combination with continued methotrexate, provided significant improvement in disease activity at Week 24, with good tolerance, in patients with severe and active RA despite anti-TNF-alpha agents and/or with contraindication to these drugs, in this daily practice study.

引用

页码：31 / 34

页数：4

共 14 条

[1]

ARNETT FC, 1987, ARTHRITIS RHEUM, V31, P315

[2]

Assous N, 2007, CLIN EXP RHEUMATOL, V25, P504

[3] Efficacy of B cell depletion in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor α agents:: an open-label observational study [J].

Brulhart, L. ;

Ciurea, A. ;

Finckh, A. ;

Notter, A. ;

Waldburger, J. M. ;

Kyburz, D. ;

Gabay, C. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (09) :1255-1257

[4] Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy - Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks [J].

Cohen, Stanley B. ;

Emery, Paul ;

Greenwald, Maria W. ;

Dougados, Maxime ;

Furie, Richard A. ;

Genovese, Mark C. ;

Keystone, Edward C. ;

Loveless, James E. ;

Burmester, Gerd-Ruediger ;

Cravets, Matthew W. ;

Hessey, Eva W. ;

Shaw, Timothy ;

Totoritis, Mark C. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (09) :2793-2806

[5] Tumor necrosis factor-α antagonists for the treatment of rheumatic diseases [J].

Criscione, LG ;

St Clair, EW .

CURRENT OPINION IN RHEUMATOLOGY, 2002, 14 (03) :204-211

[6] Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis [J].

Edwards, JCW ;

Szczepanski, L ;

Szechinski, J ;

Filipowicz-Sosnowska, A ;

Emery, P ;

Close, DR ;

Stevens, RM ;

Shaw, T .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (25) :2572-2581

[7] The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment - Results of a phase IIb randomized, double-blind, placebo-controlled, dose-ranging trial [J].

Emery, P ;

Fleischmann, R ;

Filipowicz-Sosnowska, A ;

Schechtman, J ;

Szczepanski, L ;

Kavanaugh, A ;

Racewicz, AJ ;

Van Vollenhoven, RF ;

Li, NF ;

Agarwal, S ;

Hessey, EW ;

Shaw, TM .

ARTHRITIS AND RHEUMATISM, 2006, 54 (05) :1390-1400

[8]

Fransen J, 2005, CLIN EXP RHEUMATOL, V23, pS93

[9]

Higashida J, 2005, J RHEUMATOL, V32, P2109

[10] Rituximab therapy in patients with resistant rheumatoid arthritis: real-life experience [J].

Jois, R. N. ;

Masilling, A. ;

Somerville, M. ;

Gaffney, K. ;

Scott, D. G. I. .

RHEUMATOLOGY, 2007, 46 (06) :980-982

← 1 2 →