Obesity and COVID-19: What are the Consequences?

被引:20
作者
Steenblock, Charlotte [1 ]
Hassanein, Mohamed [2 ]
Khan, Emran G. [3 ]
Yaman, Mohamad [4 ]
Kamel, Margrit [5 ]
Barbir, Mahmoud [6 ]
Lorke, Dietrich E. [7 ]
Everett, Dean [8 ]
Bejtullah, Saqipi [9 ]
Lohmann, Tobias [10 ]
Lindner, Uwe [11 ]
Tahirukaj, Ermal [1 ]
Jirjees, Feras Jassim [12 ]
Soliman, Sameh S. M. [12 ]
Quitter, Friederike [13 ]
Bornstein, Stefan R. [1 ,14 ]
机构
[1] Univ Klinikum Carl Gustav Carus, Dept Med 3, Dresden, Germany
[2] Dubai Hosp, Dept Diabet & Endocrinol, Dubai, U Arab Emirates
[3] Kings Coll Hosp London, Endocrinol & Diabetol, Dubai, U Arab Emirates
[4] Nesmah Technol, Bldg 6, Dubai, U Arab Emirates
[5] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, Dresden, Germany
[6] Harefield Hosp, Dept Cardiol, Harefield, Middx, England
[7] Khalifa Univ, Dept Anat & Cellular Biol, Abu Dhabi, U Arab Emirates
[8] Khalifa Univ, Dept Pathol & Infect Dis, Abu Dhabi, U Arab Emirates
[9] Coll Heimerer, Res Unit, Prishtina, Kosovo
[10] Stadt Klinikum Dresden, MK5, Dresden, Germany
[11] Klinikum Chemnitz, Internal Med 2, Chemnitz, Germany
[12] Univ Sharjah, Coll Pharm, Sharjah, U Arab Emirates
[13] Univ Klinikum Carl Gustav Carus, Klin Kinder & Jugendmed, Dresden, Germany
[14] Kings Coll London, Fac Life Sci & Med, Sch Cardiovasc & Metab Med & Sci, London, England
关键词
obesity; metabolic syndrome; COVID-19; long-COVID; inflammation; ADIPOSE-TISSUE BIOLOGY; CIRCULATING ADIPONECTIN; INFLAMMATION; CORONAVIRUS; OVERWEIGHT; EXPRESSION; BINDING; ACE2; SEX;
D O I
10.1055/a-1878-9757
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity is an increasing health problem all over the world. In combination with the current COVID-19 pandemic, this has turned into a massive challenge as individuals with overweight and obesity at all ages show a significant increase in their risk of getting severe COVID-19. Around 20% of all patients that were hospitalized for COVID-19 suffered from obesity alone, whereas obesity in combination with other metabolic comorbidities, such as type 2 diabetes and hypertension, account for up to 60% of all hospitalizations in relation to COVID-19. Therefore, it is of immense importance to put the spotlight on the high incidence of obesity present already in childhood both by changing the individual minds and by encouraging politicians and the whole society to commence preventive interventions for achieving a better nutrition for all social classes all over the world. In the current review, we aim to explain the different pathways and mechanisms that are responsible for the increased risk of severe COVID-19 in people with overweight and obesity. Furthermore, we discuss how the pandemic has led to weight gains in many people during lockdown. At the end, we discuss the importance of preventing such an interface between a non-communicable disease like obesity and a communicable disease like COVID-19 in the future.
引用
收藏
页码:496 / 502
页数:7
相关论文
共 89 条
  • [31] Obesity after the Covid-19 pandemic and beyond
    Kiess, Wieland
    Kirstein, Anna S.
    Stein, Robert
    Vogel, Mandy
    [J]. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2022, 35 (02) : 135 - 138
  • [32] Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea
    Kim, Yoonjung
    Bitna-Ha
    Kim, Shin-Woo
    Chang, Hyun-Ha
    Kwon, Ki Tae
    Bae, Sohyun
    Hwang, Soyoon
    [J]. BMC INFECTIOUS DISEASES, 2022, 22 (01)
  • [33] Climate Change and Obesity
    Koch, Christian A.
    Sharda, Pankaj
    Patel, Jay
    Gubbi, Sriram
    Bansal, Rashika
    Bartel, Michael J.
    [J]. HORMONE AND METABOLIC RESEARCH, 2021, 53 (09) : 575 - 587
  • [34] Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART-CT Study
    Kott, Katharine A.
    Morel-Kopp, Marie-Christine
    Vernon, Stephen T.
    Takagi, Yuki
    Di Bartolo, Belinda A.
    Peter, Karlheinz
    Yang, Jean Y.
    Grieve, Stuart M.
    Ward, Christopher
    Figtree, Gemma A.
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021, 10 (20):
  • [35] Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    Kumada, M
    Kihara, S
    Ouchi, N
    Kobayashi, H
    Okamoto, Y
    Ohashi, K
    Maeda, K
    Nagaretani, H
    Kishida, K
    Maeda, N
    Nagasawa, A
    Funahashi, T
    Matsuzawa, Y
    [J]. CIRCULATION, 2004, 109 (17) : 2046 - 2049
  • [36] COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury
    Lasbleiz, Adele
    Gaborit, Benedicte
    Soghomonian, Astrid
    Bartoli, Axel
    Ancel, Patricia
    Jacquier, Alexis
    Dutour, Anne
    [J]. FRONTIERS IN ENDOCRINOLOGY, 2021, 12
  • [37] Adipokines in obesity
    Leal, Viviane de Oliveira
    Mafra, Denise
    [J]. CLINICA CHIMICA ACTA, 2013, 419 : 87 - 94
  • [38] Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    Lumeng, Carey N.
    Bodzin, Jennifer L.
    Saltiel, Alan R.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (01) : 175 - 184
  • [39] Obesity Increases the Duration of Influenza A Virus Shedding in Adults
    Maier, Hannah E.
    Lopez, Roger
    Sanchez, Lopez
    Ng, Sophia
    Gresh, Lionel
    Ojeda, Sergio
    Burger-Calderon, Raquel
    Kuan, Guillermina
    Harris, Eva
    Balmaseda, Angel
    Gordon, Aubree
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2018, 218 (09) : 1378 - 1382
  • [40] Obesity and immune system impairment: A global problem during the COVID-19 pandemic
    Manca, Rosa
    Bombillar, Francisco
    Glomski, Chester
    Pica, Alessandra
    [J]. INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE, 2022, 33 (02) : 193 - 208