Isolation of a Novel Aggregatibacter actinomycetemcomitans Serotype b Bacteriophage Capable of Lysing Bacteria within a Biofilm

被引：31

作者：

Castillo-Ruiz, Mario ^{[1
]}

Vines, Enrique D. ^{[1
]}

Montt, Camilo ^{[1
]}

Fernandez, Jorge ^{[2
]}

Manuel Delgado, Jose ^{[3
]}

Carlos Hormazabal, Juan ^{[4
]}

Bittner, Mauricio ^{[1
,5
]}

机构：

[1] Univ Andres Bello, Lab Microbiol & Biotecnol Oral, Fac Ciencias Biol, Santiago, Chile

[2] Inst Salud Publ Chile, Dept Mol Genet, Santiago, Chile

[3] Univ Andres Bello, Fac Med, Santiago, Chile

[4] Inst Salud Publ Chile, Dept Microbiol, Santiago, Chile

[5] Univ Andres Bello, Fac Odontol, Santiago, Chile

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 09期

关键词：

ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PORPHYROMONAS-GINGIVALIS; IN-VITRO; PERIODONTAL PATHOGENS; DISEASES; SYSTEM; HEALTH; PLAQUE; MODEL;

D O I：

10.1128/AEM.02115-10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.

引用

页码：3157 / 3159

页数：3