Isolation of a Novel Aggregatibacter actinomycetemcomitans Serotype b Bacteriophage Capable of Lysing Bacteria within a Biofilm

被引:31
|
作者
Castillo-Ruiz, Mario [1 ]
Vines, Enrique D. [1 ]
Montt, Camilo [1 ]
Fernandez, Jorge [2 ]
Manuel Delgado, Jose [3 ]
Carlos Hormazabal, Juan [4 ]
Bittner, Mauricio [1 ,5 ]
机构
[1] Univ Andres Bello, Lab Microbiol & Biotecnol Oral, Fac Ciencias Biol, Santiago, Chile
[2] Inst Salud Publ Chile, Dept Mol Genet, Santiago, Chile
[3] Univ Andres Bello, Fac Med, Santiago, Chile
[4] Inst Salud Publ Chile, Dept Microbiol, Santiago, Chile
[5] Univ Andres Bello, Fac Odontol, Santiago, Chile
关键词
ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PORPHYROMONAS-GINGIVALIS; IN-VITRO; PERIODONTAL PATHOGENS; DISEASES; SYSTEM; HEALTH; PLAQUE; MODEL;
D O I
10.1128/AEM.02115-10
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.
引用
收藏
页码:3157 / 3159
页数:3
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