The calpain system and cancer

被引：317

作者：

Storr, Sarah J. ^{[1
]}

Carragher, Neil O. ^{[2
]}

Frame, Margaret C. ^{[2
]}

Parr, Tim ^{[3
]}

Martin, Stewart G. ^{[1
]}

机构：

[1] Univ Nottingham, Nottingham Univ Hosp NHS Trust, Sch Mol Med Sci, Acad Oncol, Nottingham NG5 1PB, England

[2] Western Gen Hosp, Inst Genet & Mol Med, Edinburgh Canc Res UK Ctr, Edinburgh EH4 2XR, Midlothian, Scotland

[3] Univ Nottingham, Sch Biosci, Div Nutr Sci, Loughborough LE12 5RD, Leics, England

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ACTIVATED NEUTRAL PROTEASE; CALCIUM-DEPENDENT PROTEASE; NF-KAPPA-B; CISPLATIN-INDUCED APOPTOSIS; EPIDERMAL-GROWTH-FACTOR; TUMOR-CELL MIGRATION; HUMAN-MELANOMA CELLS; F HAND STRUCTURE; MU-CALPAIN; SKELETAL-MUSCLE;

D O I：

10.1038/nrc3050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellular signalling, apoptosis and cell survival. Calpain expression is altered during tumorigenesis, and the proteolysis of numerous substrates, such as inhibitors of nuclear factor-kappa B (I kappa B), focal adhesion proteins (including, focal adhesion kinase and talin) and proto-oncogenes (for example, MYC), has been implicated in tumour pathogenesis. Recent evidence indicates that the increased expression of certain family members might influence the response to cancer therapies, providing justification for the development of novel calpain inhibitors.

引用

页码：364 / 374

页数：11

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