Serial neurosonography in fetuses with congenital heart defects shows mild delays in cortical development

被引:1
|
作者
Everwijn, Sheila M. [1 ]
van Bohemen, Jiska F. [2 ]
van Geloven, Nan [3 ]
Jansen, Fenna A. [1 ]
Teunissen, Aalbertine K. [1 ]
Rozendaal, Lieke [4 ]
Blom, Nico [4 ]
van Lith, Jan M. [1 ]
Haak, Monique C. [1 ]
机构
[1] Leiden Univ Med Ctr, Dept Obstet & Prenatal Diag, Leiden, Netherlands
[2] HAGA Hosp, Dept Obstet & Gynecol, The Hague, Netherlands
[3] Leiden Univ Med Ctr, Dept Biomed Data Sci, Leiden, Netherlands
[4] Leiden Univ Med Ctr, Dept Pediat Cardiol, Leiden, Netherlands
关键词
GREAT-ARTERIES; BRAIN; INFANTS; TRANSPOSITION; BIOMETRY;
D O I
10.1002/pd.6038
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Introduction Neurodevelopmental delay is more common in children born with congenital heart defects (CHD), even with optimal perinatal and peri-operative care. It is hypothesized that fetuses with CHD are prone to neurological impairment in utero due to their cardiac defect, possibly leading to delayed cortical development. Methods Cerebral cortical maturation was assessed with advanced neurosonographic examinations every 4 weeks in fetuses with CHD and compared to control fetuses. Five different primary fissures and four areas were scored (ranging 0-5) by blinded examiners using a cortical maturation scheme. Results Cortical staging was assessed in 574 ultrasound examinations in 85 CHD fetuses and 61 controls. Small differences in grading were seen in Sylvian and cingulate fissures. (Sylvian fissure: -0.12 grade, 95% CI (-0.23; -0.01) p = 0.05, cingulate fissure: -0.24 grade, 95% CI (-0.38; -0.10) p = <0.001. Other cortical areas showed normal maturation as compared to control fetuses. Conclusion Small differences were seen in three of the nine analyzed cortical areas in CHD fetuses, in contrast to previous reports on progressive third-trimester delay. The clinical implications of the small differences however, remain unknown.
引用
收藏
页码:1649 / 1657
页数:9
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