The biology, function, and applications of exosomes in cancer

被引：390

作者：

Liu, Jinyi

Ren, Liwen

Li, Sha

Li, Wan

Zheng, Xiangjin

Yang, Yihui

Fu, Weiqi

Yi, Jie

Wang, Jinhua

Du, Guanhua

机构：

[1] The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing

[2] Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing

[3] Department of Clinical Laboratory, Peking Union Medical College Hospital, Beijing

来源：

ACTA PHARMACEUTICA SINICA B | 2021年 / 11卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Exosomes; Tumor immunity; Tumor metastasis; Drug resistance; Biomarkers; Drug delivery; CELL-DERIVED EXOSOMES; METASTATIC NICHE FORMATION; EXTRACELLULAR VESICLES; DRUG-RESISTANCE; MULTIVESICULAR BODIES; SECRETION; PROTEINS; BIOGENESIS; BIOMARKERS; EXPRESSION;

D O I：

10.1016/j.apsb.2021.01.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial-mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive bio-markers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy. (c) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：2783 / 2797

页数：15

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