All-Optical and Label-Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials

被引:14
作者
Bruno, Giulia [1 ]
Melle, Giovanni [1 ]
Barbaglia, Andrea [1 ]
Iachetta, Giuseppina [1 ]
Melikov, Rustamzhon [1 ]
Perrone, Michela [1 ]
Dipalo, Michele [1 ]
De Angelis, Francesco [1 ]
机构
[1] Ist Italiano Tecnol, Plasmon Nanotechnol, I-16163 Genoa, Italy
基金
欧洲研究理事会;
关键词
cardiomyocytes; complementary metal-oxide semiconductor multielectrode arrays; metamaterials; microelectrode arrays; neurons; plasmonic optical stimulation; plasmonics; CELL-DERIVED CARDIOMYOCYTES; CARDIAC-MUSCLE; RAT; MATURATION; OPTOGENETICS; TERMINATION; MODULATION;
D O I
10.1002/advs.202100627
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Optical stimulation technologies are gaining great consideration in cardiology, neuroscience studies, and drug discovery pathways by providing control over cell activity with high spatio-temporal resolution. However, this high precision requires manipulation of biological processes at genetic level concealing its development from broad scale application. Therefore, translating these technologies into tools for medical or pharmacological applications remains a challenge. Here, an all-optical nongenetic method for the modulation of electrogenic cells is introduced. It is demonstrated that plasmonic metamaterials can be used to elicit action potentials by converting near infrared laser pulses into stimulatory currents. The suggested approach allows for the stimulation of cardiomyocytes and neurons directly on commercial complementary metal-oxide semiconductor microelectrode arrays coupled with ultrafast pulsed laser, providing both stimulation and network-level recordings on the same device.
引用
收藏
页数:11
相关论文
共 47 条
  • [1] A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons
    Abbott, Jeffrey
    Ye, Tianyang
    Krenek, Keith
    Gertner, Rona S.
    Ban, Steven
    Kim, Youbin
    Qin, Ling
    Wu, Wenxuan
    Park, Hongkun
    Ham, Donhee
    [J]. NATURE BIOMEDICAL ENGINEERING, 2020, 4 (02) : 232 - 241
  • [2] Cardiac applications of optogenetics
    Ambrosi, Christina M.
    Klimas, Aleksandra
    Yu, Jinzhu
    Entcheva, Emilia
    [J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2014, 115 (2-3) : 294 - 304
  • [3] Optogenetic Control of Cardiac Function
    Arrenberg, Aristides B.
    Stainier, Didier Y. R.
    Baier, Herwig
    Huisken, Jan
    [J]. SCIENCE, 2010, 330 (6006) : 971 - 974
  • [4] Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes
    Bingen, Brian O.
    Engels, Marc C.
    Schalij, Martin J.
    Jangsangthong, Wanchana
    Neshati, Zeinab
    Feola, Iolanda
    Ypey, Dirk L.
    Askar, Said F. A.
    Panfilov, Alexander V.
    Pijnappels, Daniel A.
    de Vries, Antoine A. F.
    [J]. CARDIOVASCULAR RESEARCH, 2014, 104 (01) : 194 - 205
  • [5] Atrium-Specific Kir3.x Determines Inducibility, Dynamics, and Termination of Fibrillation by Regulating Restitution-Driven Alternans
    Bingen, Brian O.
    Neshati, Zeinab
    Askar, Said F. A.
    Kazbanov, Ivan V.
    Ypey, Dirk L.
    Panfilov, Alexander V.
    Schalij, Martin J.
    de Vries, Antoine A. F.
    Pijnappels, Daniel A.
    [J]. CIRCULATION, 2013, 128 (25) : 2732 - +
  • [6] International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
    Blinova, Ksenia
    Dang, Qianyu
    Millard, Daniel
    Smith, Godfrey
    Pierson, Jennifer
    Guo, Liang
    Brock, Mathew
    Lu, Hua Rong
    Kraushaar, Udo
    Zeng, Haoyu
    Shi, Hong
    Zhang, Xiaoyu
    Sawada, Kohei
    Osada, Tomoharu
    Kanda, Yasunari
    Sekino, Yuko
    Pang, Li
    Feaster, Tromondae K.
    Kettenhofen, Ralf
    Stockbridge, Norman
    Strauss, David G.
    Gintant, Gary
    [J]. CELL REPORTS, 2018, 24 (13): : 3582 - 3592
  • [7] Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
    Blinova, Ksenia
    Stohlman, Jayna
    Vicente, Jose
    Chan, Dulciana
    Johannesen, Lars
    Hortigon-Vinagre, Maria P.
    Zamora, Victor
    Smith, Godfrey
    Crumb, William J.
    Pang, Li
    Lyn-Cook, Beverly
    Ross, James
    Brock, Mathew
    Chvatal, Stacie
    Millard, Daniel
    Galeotti, Loriano
    Stockbridge, Norman
    Strauss, David G.
    [J]. TOXICOLOGICAL SCIENCES, 2017, 155 (01) : 234 - 247
  • [8] Optocapacitive Generation of Action Potentials by Microsecond Laser Pulses of Nanojoule Energy
    Carvalho-de-Souza, Joao L.
    Pinto, Bernardo I.
    Pepperberg, David R.
    Bezanilla, Francisco
    [J]. BIOPHYSICAL JOURNAL, 2018, 114 (02) : 283 - 288
  • [9] Optogenetics and Translational Medicine
    Chow, Brian Y.
    Boyden, Edward S.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (177)
  • [10] HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
    Claycomb, WC
    Lanson, NA
    Stallworth, BS
    Egeland, DB
    Delcarpio, JB
    Bahinski, A
    Izzo, NJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) : 2979 - 2984