Asymmetric synthesis of functionalized trans-2,6-disubstituted piperidines with N-Sulfinyl δ-amino β-ketoesters.: Synthesis of (-)-lasubine I

被引：63

作者：

Davis, FA ^{[1
]}

Rao, A

Carroll, PJ

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 21期

关键词：

D O I：

10.1021/ol035390j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The hydroxy-directed reduction of 1,2-dehydropiperidines with the "ate" complex of DIBAL-H and n-BuLi affords functionalized trans-2,6-disubstituted piperidines. This methodology was employed in the asymmetric synthesis of the quinolizidine alkaloid (-)-lasubine I.

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页码：3855 / 3857

页数：3

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