The second brain: The connection between gut microbiota composition and multiple sclerosis

被引：21

作者：

Farshbafnadi, Melina ^{[1
]}

Agah, Elmira ^{[2
]}

Rezaei, Nima ^{[3
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[2] Univ Tehran Med Sci, Univ Sci Educ & Res Network USERN, NeuroImmunol Res Assoc NIRA, Students Sci Res Ctr,Iranian Ctr Neurol Res,Neuro, Tehran, Iran

[3] Univ Tehran Med Sci, Network Immun Infect Malignancy & Autoimmun NIIMA, Univ Sci Educ & Res Network USERN, Dept Immunol,Sch Med,Childrens Med Ctr,Res Ctr Im, Tehran, Iran

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 360卷

关键词：

MATERNAL SEPARATION; AXIS; DISEASE; HEALTH; BOWEL; MODEL;

D O I：

10.1016/j.jneuroim.2021.577700

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gut microbiota composition may affect the central nervous system (CNS) and immune function. Several studies have recently examined the possible link between gut microbiota composition and multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Most of these studies agree that patients with MS suffer from dysbiosis. Moreover, an altered proportion of certain phyla of bacteria was detected in the digestive tracts of these patients compared to healthy individuals. This review article gathers information from research papers that have examined the relationship between gut microbiota composition and MS and its possible mechanisms.

引用

页数：8

共 69 条

[1] Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome [J].

Al-Ghezi, Zinah Zamil ;

Busbee, Philip Brandon ;

Alghetaa, Hasan ;

Nagarkatti, Prakash S. ;

Nagarkatti, Mitzi .

BRAIN BEHAVIOR AND IMMUNITY, 2019, 82 :25-35

[2] Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity? [J].

Antel, Jack ;

Antel, Samson ;

Caramanos, Zografos ;

Arnold, Douglas L. ;

Kuhlmann, Tanja .

ACTA NEUROPATHOLOGICA, 2012, 123 (05) :627-638

[3] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[4]

Bailey MT, 1999, DEV PSYCHOBIOL, V35, P146, DOI 10.1002/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO

[5]

2-G

[6] Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells [J].

Benedek, Gil ;

Zhang, Jun ;

Ha Nguyen ;

Kent, Gail ;

Seifert, Hilary A. ;

Davin, Sean ;

Stauffer, Patrick ;

Vandenbark, Arthur A. ;

Karstens, Lisa ;

Asquith, Mark ;

Offner, Halina .

JOURNAL OF NEUROIMMUNOLOGY, 2017, 310 :51-59

[7] Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status [J].

Berer, Kerstin ;

Martinez, Ines ;

Walker, Alesia ;

Kunkel, Birgit ;

Schmitt-Kopplin, Philippe ;

Walter, Jens ;

Krishnamoorthy, Gurumoorthy .

SCIENTIFIC REPORTS, 2018, 8

[8] Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice [J].

Berer, Kerstin ;

Gerdes, Lisa Ann ;

Cekanaviciute, Egle ;

Jia, Xiaoming ;

Xiao, Liang ;

Xia, Zhongkui ;

Liu, Chuan ;

Klotz, Luisa ;

Stauffer, Uta ;

Baranzini, Sergio E. ;

Kuempfel, Tania ;

Hohlfeld, Reinhard ;

Krishnamoorthy, Gurumoorthy ;

Wekerle, Hartmut .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (40) :10719-10724

[9] Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination [J].

Berer, Kerstin ;

Mues, Marsilius ;

Koutrolos, Michail ;

Al Rasbi, Zakeya ;

Boziki, Marina ;

Johner, Caroline ;

Wekerle, Hartmut ;

Krishnamoorthy, Gurumoorthy .

NATURE, 2011, 479 (7374) :538-U266

[10] The gut microbiota influences blood-brain barrier permeability in mice [J].

Braniste, Viorica ;

Al-Asmakh, Maha ;

Kowal, Czeslawa ;

Anuar, Farhana ;

Abbaspour, Afrouz ;

Toth, Miklos ;

Korecka, Agata ;

Bakocevic, Nadja ;

Ng, Lai Guan ;

Kundu, Parag ;

Gulyas, Balazs ;

Halldin, Christer ;

Hultenby, Kjell ;

Nilsson, Harriet ;

Hebert, Hans ;

Volpe, Bruce T. ;

Diamond, Betty ;

Pettersson, Sven .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (263)

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