Emergence of dual resistance to zidovudine and lamivudine in clinical HIV-1 isolates from patients receiving zidovudine/lamivudine combination therapy

被引：0
作者：
Gass, RJA
Shugarts, D
Young, R
Allen, M
Rosandich, M
Kuritzkes, DR
机构：
[1] Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Denver, CO 80262 USA
[2] Vet Affairs Med Ctr, Denver, CO USA
来源：
ANTIVIRAL THERAPY | 1998年 / 3卷 / 02期
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D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Susceptibility to zidovudine and lamivudine was determined on human immunodeficiency virus type 1 (HIV-1) isolates obtained from patients who added lamivudine after 6 months of treatment with zidovudine. Lamivudine-resistant isolates that were also zidovudine-resistant were recovered from 13/16 (81%) patients after 6 months of dual therapy. In contrast to findings in antiretroviral therapy-naive patients, these results suggest that dual resistance to zidovudine and lamivudine emerges relatively quickly when lamivudine is added to zidovudine as a single agent in the majority of patients with extensive prior zidovudine treatment.
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页码：97 / 102
页数：6
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