A DNA logic gate based on strand displacement reaction and rolling circle amplification, responding to multiple low-abundance DNA fragment input signals, and its application in detecting miRNAs

被引：44

作者：

Chen, Yuqi ^{[1
]}

Song, Yanyan ^{[1
]}

Wu, Fan ^{[1
]}

Liu, Wenting ^{[1
]}

Fu, Boshi ^{[1
]}

Feng, Bingkun ^{[1
]}

Zhou, Xiang ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 32期

基金：

美国国家科学基金会;

关键词：

MOLECULAR LOGIC; METAL-IONS; CANCER; PROBES; CELLS; COMPUTATION; CIRCUITS; GROWTH;

D O I：

10.1039/c5cc01389e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A conveniently amplified DNA AND logic gate platform was designed for the highly sensitive detection of low-abundance DNA fragment inputs based on strand displacement reaction and rolling circle amplification strategy. Compared with others, this system can detect miRNAs in biological samples. The success of this strategy demonstrates the potential of DNA logic gates in disease diagnosis.

引用

页码：6980 / 6983

页数：4

共 40 条

[1] MOLECULAR COMPUTATION OF SOLUTIONS TO COMBINATORIAL PROBLEMS [J].

ADLEMAN, LM .

SCIENCE, 1994, 266 (5187) :1021-1024

[2] let-7 microRNA functions as a potential growth suppressor in human colon cancer cells [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Naoe, Tomoki .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (05) :903-906

[3] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[4] Selective Manipulation of ICT and PET Processes in Styryl-Bodipy Derivatives: Applications in Molecular Logic and Fluorescence Sensing of Metal Ions [J].

Bozdemir, O. Altan ;

Guliyev, Ruslan ;

Buyukcakir, Onur ;

Selcuk, Sencer ;

Kolemen, Safacan ;

Gulseren, Gulcihan ;

Nalbantoglu, Tugrul ;

Boyaci, Hande ;

Akkaya, Engin U. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (23) :8029-8036

[5] Sensitive and Label-Free DNA Methylation Detection by Ligation-Mediated Hyperbranched Rolling Circle Amplification [J].

Cao, Anping ;

Zhang, Chun-yang .

ANALYTICAL CHEMISTRY, 2012, 84 (14) :6199-6205

[6] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

[7] Using a deoxyribozyme ligase and rolling circle amplification to detect a non-nucleic acid analyte, ATP [J].

Cho, EJ ;

Yang, LT ;

Levy, M ;

Ellington, AD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (07) :2022-2023

[8]

de Ruiter G., 2010, ANGEW CHEM, V122, P173

[9]

de Ruiter G., 2010, ANGEW CHEM, V122, P4890

[10] Molecular logic and computing [J].

de Silva, A. Prasanna ;

Uchiyama, Seiichi .

NATURE NANOTECHNOLOGY, 2007, 2 (07) :399-410

← 1 2 3 4 →