Obesity, Inflammation, and Cancer

被引:591
作者
Deng, Tuo [1 ,2 ,3 ]
Lyon, Christopher J. [1 ,2 ]
Bergin, Stephen [4 ,5 ,6 ,7 ]
Caligiuri, Michael A. [6 ,7 ]
Hsueh, Willa A. [8 ]
机构
[1] Houston Methodist Res Inst, Diabet Res Ctr, Houston, TX 77030 USA
[2] Houston Methodist Res Inst, Ctr Bioenerget, Houston, TX 77030 USA
[3] Cornell Univ, Dept Med, Weill Cornell Med Coll, New York, NY 10021 USA
[4] Ohio State Univ, Med Scientist Training Program, Columbus, OH 43210 USA
[5] Ohio State Univ, Biomed Sci Grad Program, Columbus, OH 43210 USA
[6] Ohio State Univ, Arthur G James Canc Hosp, Ctr Comprehens Canc, Columbus, OH 43210 USA
[7] Ohio State Univ, Richard J Solove Res Inst, Columbus, OH 43210 USA
[8] Ohio State Univ, Dept Med, Diabet & Metab Res Ctr, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA
来源
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 | 2016年 / 11卷
关键词
cancer risk; body mass index; adipose tissue; cytokine; adipokine; metabolic dysregulation; weight loss; BODY-MASS INDEX; REGULATORY T-CELLS; INNATE LYMPHOID TYPE-2; WHITE ADIPOSE-TISSUE; FATTY LIVER-DISEASE; Y GASTRIC BYPASS; PANCREATIC-CANCER; BREAST-CANCER; INSULIN-RESISTANCE; COLORECTAL-CANCER;
D O I
10.1146/annurev-pathol-012615-044359
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions, including cancer, and is increasingly recognized as a growing cause of preventable cancer risk. Chronic inflammation, a well-known mediator of cancer, is a central characteristic of obesity, leading to many of its complications, and obesity-induced inflammation confers additional cancer risk beyond obesity itself. Multiple mechanisms facilitate this strong association between cancer and obesity. Adipose tissue is an important endocrine organ, secreting several hormones, including leptin and adiponectin, and chemokines that can regulate tumor behavior, inflammation, and the tumor microenvironment. Excessive adipose expansion during obesity causes adipose dysfunction and inflammation to increase systemic levels of proinflammatory factors. Cells from adipose tissue, such as cancer-associated adipocytes and adipose-derived stem cells, enter the cancer microenvironment to enhance protumoral effects. Dysregulated metabolism that stems from obesity, including insulin resistance, hyperglycemia, and dyslipidemia, can further impact tumor growth and development. This review describes how adipose tissue becomes inflamed in obesity, summarizes ways these mechanisms impact cancer development, and discusses their role in four adipose-associated cancers that demonstrate elevated incidence or mortality in obesity.
引用
收藏
页码:421 / 449
页数:29
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