Copper-catalyzed synthesis of 1,3,5-triary1-4-(organylselany1)-1H-pyrazoles by one-pot multicomponent reactions

被引：18

作者：

de Aquino, Thalita F. B. ^{[1
]}

Seidel, Jessica P. ^{[1
]}

de Oliveira, Daniela H. ^{[1
]}

do Nascimento, Jose Edmilson R. ^{[1
]}

Alves, Diego ^{[1
]}

Perin, Gelson ^{[1
]}

Lenardao, Eder J. ^{[1
]}

Schumacher, Ricardo F. ^{[2
]}

Jacob, Raquel G. ^{[1
]}

机构：

[1] Univ Fed Pelotas, CCQFA, LASOL, Lab Sintese Organ Limpa,UFPel, POB 354, BR-96010900 Pelotas, RS, Brazil

[2] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 46期

关键词：

Catalysis; Copper; Nitrogen heterocycles; Organoselenium compounds; Pyrazoles; ROOM-TEMPERATURE SYNTHESIS; SOLVENT-FREE; PYRAZOLES; DIAZEPINES; CYCLOCONDENSATION; HETEROCYCLES; CYCLIZATION; EFFICIENT; SELENIUM; ACID;

D O I：

10.1016/j.tetlet.2018.10.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe herein our results for the multicomponent synthesis of 1,3,5-triary1-4-(organylselanyl)pyrazoles by copper-catalyzed cyclocondensation and a direct C-H bond selenation reaction of arylhydrazines, chalcones and diorganyl diselenides using catalytic amount of CuBr in acetic acid as solvent at reflux temperature. This methodology proved to be simple and efficient to furnish a range of 4-(organylselany1)-1H-pyrazoles in moderate to good yields. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：4090 / 4095

页数：6

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