Behaviors of controlled drug release of magnetic-gelatin hydrogel coated stainless steel for drug-eluting-stents application

The behavior of drug release controlled by magnetic fields (MF) for stainless steel coated with magnetic-gelatin (MAG-GE) hydrogel was investigated in this paper. X-ray photoelectron spectroscope (XPS) and vibrating sample magnetometer were used to evaluate the characterizations of MAG-GE hydrogel and the interaction with the surface of SUS316L. A model drug (sirolimus) was loaded to the MAG-GE hydrogel. When applying MF to the MAG-GE hydrogel, the sirolimus release rate of the magnetic hydrogel decreased by 1/3, comparing to that without the field. This suggests a "close'' configuration of the MAG-GE hydrogel due to the aggregation of magnetic nanoparticles which reduced the pore size of MAG-GE hydrogel. (C) 2006 Elsevier B.V. All rights reserved.