Antibacterial and cytotoxic triterpenoids from the ethanol extract of Dysoxylum densiflorum (Blume) Miq

被引：14

作者：

Hu, Jiang ^{[1
]}

Song, Yan ^{[2
]}

Li, Hui ^{[3
]}

Mao, Xia ^{[1
]}

Zhao, Yongmao ^{[1
]}

Shi, Xiaodong ^{[1
]}

Yang, Benshou ^{[4
]}

机构：

[1] Qujing Normal Univ, Coll Biol Resources & Environm Sci, Qujing 655011, Yunnan, Peoples R China

[2] Peoples Liberat Army, Hosp 455, Dept Pharm, Shanghai 200052, Peoples R China

[3] Qujing Normal Univ, Coll Phys & Elect Engn, Qujing 655011, Yunnan, Peoples R China

[4] Qujing Med Coll, Inst Microbiol, Qujing 655000, Yunnan Province, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 10卷

关键词：

Dysoxylum densiflorum (Blume) Miq; Meliaceae; Triterpenoids; Antibacterial; Cytotoxicity; CONSTITUENTS; LENTICELLARE; SPECTABILE; MELIACEAE; RICHII;

D O I：

10.1016/j.phytol.2014.09.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A chemical investigation of the stem bark of Dysoxylum densiflorum (Blume) Miq. afforded three new triterpenoids, dysoxylumin A-C (1-3) together with two known compounds, 24-nor-5 alpha, 13 alpha, 14 alpha, 17 alpha-chola- 7,20,22-trien-3-one (4) and 24-norchola-1,20,22-triene-3,7-dione (5). Their structures were determined on the basis of spectroscopic analyses, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The isolated components were evaluated in vitro for antibacterial properties against two Gram-positive and five Gram-negative bacteria and cytotoxicities against six tumor cell lines. As a result, triterpenoids 2-5 exhibited moderate antibacterial and cytotoxic activities. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：219 / 223

页数：5

共 21 条

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