It is now well accepted that many tumors undergo a process of clonal selection which means that tumor antigens arising at various stages of tumor progression are likely to be represented in just a subset of tumor cells. This process is thought to be driven by constant immunosurveillance which applies selective pressure by eliminating tumor cells expressing antigens that are recognized by T cells. It is becoming increasingly clear that the same selective pressure may also select for tumor cells that evade immune detection by acquiring deficiencies in their human leucocyte antigen (HLA) presentation pathways, allowing important tumor antigens to persist within cells undetected by the immune system. Deficiencies in antigen presentation pathway can arise by a variety of mechanisms, including genetic and epigenetic changes, and functional antigen presentation is a hard phenomenon to assess using our standard analytical techniques. Nevertheless, it is likely to have profound clinical significance and could well define whether an individual patient will respond to a particular type of therapy or not. In this review we consider the mechanisms by which HLA function may be lost in clinical disease, we assess the implications for current immunotherapy approaches using checkpoint inhibitors and examine the prognostic impact of HLA loss demonstrated in clinical trials so far. Finally, we propose strategies that might be explored for possible patient stratification.
机构:
Univ Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Jin, Hyung-seung
Choi, Da-som
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Univ Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Choi, Da-som
Ko, Minkyung
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h-index: 0
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KIST, Biomed Res Inst, Ctr Theragnosis, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Ko, Minkyung
Kim, Dongkap
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
Hanyang Univ, Dept Chem, Seoul 04763, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Kim, Dongkap
Lee, Dong-hee
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Univ Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Lee, Dong-hee
Lee, Soojin
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KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Lee, Soojin
Lee, Ah Young
论文数: 0引用数: 0
h-index: 0
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KIST, Biomed Res Inst, Ctr Theragnosis, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Lee, Ah Young
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Kang, Seung Goo
Kim, Soo Hyun
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 136705, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Kim, Soo Hyun
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机构:
Jung, Youngmee
Jeong, Youngdo
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Jeong, Youngdo
Chung, Justin J.
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KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Chung, Justin J.
Park, Yoon
论文数: 0引用数: 0
h-index: 0
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KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
机构:
CNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, FranceCNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, France
Joly, Etienne
Rouillon, Virginie
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h-index: 0
机构:
CNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, FranceCNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, France
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Jung, Yong Wook
Kim, Young Tae
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h-index: 0
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Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Young Tae
Kim, Sang Wun
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h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Sang Wun
Kim, Sunghoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Sunghoon
Kim, Jae Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Jae Hoon
Cho, Nam Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Pathol, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Cho, Nam Hoon
Kim, Jae Wook
论文数: 0引用数: 0
h-index: 0
机构:
Kwandong Univ, Myongji Hosp, Coll Med, Dept Obstet & Gynecol, Goyang, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
机构:
Univ Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Jin, Hyung-seung
Choi, Da-som
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Choi, Da-som
Ko, Minkyung
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Theragnosis, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Ko, Minkyung
Kim, Dongkap
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
Hanyang Univ, Dept Chem, Seoul 04763, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Kim, Dongkap
Lee, Dong-hee
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Lee, Dong-hee
Lee, Soojin
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Lee, Soojin
Lee, Ah Young
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Theragnosis, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Lee, Ah Young
论文数: 引用数:
h-index:
机构:
Kang, Seung Goo
Kim, Soo Hyun
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 136705, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Kim, Soo Hyun
论文数: 引用数:
h-index:
机构:
Jung, Youngmee
Jeong, Youngdo
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea
Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Jeong, Youngdo
Chung, Justin J.
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
Chung, Justin J.
Park, Yoon
论文数: 0引用数: 0
h-index: 0
机构:
KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South KoreaUniv Ulsan, Coll Med, ASAN Med Ctr, ASAN Inst Life Sci, Seoul 05505, South Korea
机构:
CNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, FranceCNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, France
Joly, Etienne
Rouillon, Virginie
论文数: 0引用数: 0
h-index: 0
机构:
CNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, FranceCNRS, Equipe Neuroimmunogenet Mol, IPBS, UMR 5089, F-31077 Toulouse, France
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Jung, Yong Wook
Kim, Young Tae
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Young Tae
Kim, Sang Wun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Sang Wun
Kim, Sunghoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Sunghoon
Kim, Jae Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Kim, Jae Hoon
Cho, Nam Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Pathol, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea
Cho, Nam Hoon
Kim, Jae Wook
论文数: 0引用数: 0
h-index: 0
机构:
Kwandong Univ, Myongji Hosp, Coll Med, Dept Obstet & Gynecol, Goyang, South KoreaYonsei Univ, Coll Med, Dept Obstet & Gynecol, Div Gynecol Oncol,Womens Canc Clin, Seoul 120752, South Korea