Biomedical Applicable Cellulose Fabric Modified with Zirconium-Based Metal-Organic Frameworks (Zr-MOFs)

Zirconium-based metal-organic frameworks (Zr-MOFs) have been synthesized onto diverse substrates however thermal and acidic conditions of synthesis processing impair or carbonize the polysaccharide based substrate. Also, MOF-coated polysaccharides usually show poor mechanical properties and instability in aqueous conditions unsuitable for biomedical applications. There is no report on the synthesis of MOFs on cellulosic substrate to preserve intactness. Here, an optimized Zr-MOFs synthesis method on cotton fabric is introduced to prepare a biomedically applicable Zr-MOFs modified cellulosic fabric. The resultant fabric demonstrates an absolute wash durability with enhanced hydrophilicity and better mechanical properties with higher Zr-MOFs content. The treated fabric shows 787% and 2105% improvement in absorption capacity for Salvia officinalis (SO) and Calendula officinalis (CO) extracts and the release kinetic model of diffusion mechanism. Cotton-MOF-SO and Cotton-MOF-CO confirm antibacterial activity of 99.2% and 37.4% against Escherichia coli and 19.9% and 35.3% against Staphylococcus aureus. Finally, the cotton-MOF-CO can be considered as a biocompatible material however cotton-MOF-SO exhibits high toxicity signifying its potentiality for inducing death to cancer cells.