Iron and erythropoiesis: a dual relationship

被引：18

作者：

Camaschella, Clara ^{[1
,2
]}

Pagani, Alessia ^{[1
,2
]}

机构：

[1] Univ Vita Salute, Div Genet & Cell Biol, I-20132 Milan, Italy

[2] IRCCS San Raffaele, I-20132 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2011年 / 93卷 / 01期

关键词：

Iron; Erythropoiesis; Hepcidin; PROTEASE MATRIPTASE-2 TMPRSS6; LINKED SIDEROBLASTIC ANEMIA; MICROCYTIC ANEMIA; SERINE-PROTEASE; HEPCIDIN PRODUCTION; GENE; DEFICIENCY; MUTATIONS; MICE; CELL;

D O I：

10.1007/s12185-010-0743-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Iron is essential for cell life and especially for erythropoiesis which is the major body consumer of iron for red cell production. The study of genetic disorders of iron metabolism, the identification of iron transporters and of the role of hepcidin as the key regulator of systemic iron homeostasis have greatly contributed to our understanding of iron handling by the erythroid marrow. Spontaneous and engineered animal models of iron disorders have help to add further insights to the issue. A still incompletely understood aspect remains the regulation that erythropoiesis exerts on iron.

引用

页码：21 / 26

页数：6

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