Radiofrequency-Triggered Tumor-Targeting Delivery System for Theranostics Application

被引：39
|
作者：
Wang, Lei [1 ,2 ]
Zhang, Panpan [2 ]
Shi, Jinjin [2 ]
Hao, Yongwei [2 ]
Meng, Dehui [2 ]
Zhao, Yalin [2 ]
Yin Yanyan [3 ]
Li, Dong [2 ]
Chang, Junbiao [1 ]
Zhang, Zhenzhong [2 ]
机构：
[1] Zhengzhou Univ, Sch Chem & Mol Engn, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
[3] Zhengzhou Univ, Sch Publ Hlth, Zhengzhou 450001, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 10期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
thermosensitive magnetoliposomes; gold nanoshells; dual-mode MR/X-ray imaging controlled release; chemo-hyperthermia therapy; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; LIPOSOMAL DOXORUBICIN; PHOTOTHERMAL THERAPY; GOLD NANOPARTICLES; MAGNETIC LIPOSOMES; GREEN SYNTHESIS; TOXICITY; VIVO;
D O I：
10.1021/am507898z
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this study, a new type of magnetic tuniot-targeting P-B-Gylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes Was successfully obtaitied. The reversephase evaporation method was used to construct the magnetoliposorneS, and then gold nanoShells were coated on the Surface Of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG(2000) modification. This rimItifunction system was combined with a variety of functions, such as radiofrequenty-triggered release, cherno-hyperthermia therapy, and dual-Mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AUNSs-PEG Complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosornal degradation. All results in vitro and in vivo indicated that DOX=TSMLs,AuNSs-PBG is a promising effective drug delivery system for diagnosis and treatment of tumors.
引用
收藏
页码：5736 / 5747
页数：12
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