Allergen Immunotherapy in Asthma

被引：18

作者：

Nakagome, Kazuyuki ^{[1
,2
]}

Nagata, Makoto ^{[1
,2
]}

机构：

[1] Saitama Med Univ, Dept Resp Med, Saitama 3500495, Japan

[2] Saitama Med Univ, Allergy Ctr, Saitama 3500495, Japan

来源：

PATHOGENS | 2021年 / 10卷 / 11期

关键词：

allergen immunotherapy; bronchial asthma; subcutaneous immunotherapy; sublingual immunotherapy; GRASS-POLLEN IMMUNOTHERAPY; HOUSE-DUST MITE; REGULATORY B-CELLS; SUBLINGUAL IMMUNOTHERAPY; CLINICAL-EFFICACY; DOUBLE-BLIND; T-CELLS; DERMATOPHAGOIDES-PTERONYSSINUS; INHALED BUDESONIDE; IMMUNOGLOBULIN G4;

D O I：

10.3390/pathogens10111406

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Allergen immunotherapy (AIT) is a specific treatment involving the administration of relevant allergens to allergic patients, with subtypes including subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). In asthma, AIT using the house dust mite (HDM) alleviates clinical symptoms and decreases airway hyper responsiveness and medication dose. In addition, AIT can improve the natural course of asthma. For example, the effects of AIT can be preserved for at least a few years, even after ending treatment. AIT may increase the remission rate of asthma in children and suppress sensitization to new allergens. If AIT is introduced in pollinosis, AIT may prevent the development of asthma. Moreover, AIT can control other allergic diseases complicated by asthma, such as allergic rhinitis, which also improves the control of asthma. The indication of HDM-SCIT for asthma is mild-to-moderate HDM-sensitized allergic asthma in a patient with normal respiratory function. To date, HDM-SLIT is applicable in Japan for allergic rhinitis, not for asthma. However, the effect of SLIT on asthma has been confirmed internationally, and SLIT is available for asthma in Japan if allergic rhinitis is present as a complication.

引用

页数：10

共 77 条

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